May 6, 2020 · Herein, an Angiopep-2 (Ang) functionalized intracellular-environment-responsive siRNA nanocapsule (Ang-NC ss (siRNA)) is successfully developed as a safe and efficient …

Our single siRNA nanocapsule platform, illustrated in Scheme 1, starts with a new monomer A (positively charged), crosslinker B, monomer C (neutral), and enriches these molecules …

Aug 22, 2012 · To address this challenge, we present here a single siRNA nanocapsule delivery technology, which is achieved by encapsulating a single siRNA molecule within a degradable …

Apr 15, 2023 · The cationic-free nanocapsules with siRNA cores not only showed great performance (such as efficient siRNA encapsulation, high stability in serum, cancer cell …

Mar 1, 2021 · A siRNA-loaded Nanosac is produced by sequential coating of mesoporous silica nanoparticles (MSNs) with siRNA and polydopamine, followed by removal of the sacrificial …

Jan 1, 2015 · The cytosolic delivery of siRNA resulted in highly efficient (90%) knockdown of a destabilized green fluorescence protein (deGFP) in deGFP-HEK293 cells. Moreover, the …

Mar 3, 2021 · siRNA-loaded nanocapsules (O/siRNA/pD, Nanosac) were prepared by adsorbing siRNA on amine-modified mesoporous silica nanoparticles (MSNs), coating the siRNA-bound …

Mar 23, 2021 · As a carrier of siRNA targeting PD-L1, Nanosac induces a significant attenuation of CT26 tumor growth by immune checkpoint blockade. These results support the utility of …

Single siRNA Nanocapsules for Effective siRNA Brain Delivery and Glioblastoma Treatment

Nanoparticle-stabilized nanocapsules (NPSCs) are used to deliver TNF-α targeted siRNA for inflammation therapy. NPSC siRNA delivery effectively prevents cytokine production in LPS …