The soluble interleukin 6 receptor: mechanisms of production …
A key feature in the regulation of IL-6 responses has been the identification of a soluble interleukin 6 receptor (sIL-6R), which forms a ligand-receptor complex with IL-6 that is capable …
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R ...
Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred …
IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for …
IL-6 Classic-signaling requires membrane bound IL-6R and is restricted to hepatocytes, some epithelial cells and some leukocytes. IL-6 trans-signaling requires sIL-6R and is possible on all …
sIL-6R: more than an agonist? - PubMed
On target cells, interleukin-6 (IL-6) interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a …
The IL-6/sIL-6R complex as a novel target for therapeutic ... - PubMed
IL-6 plays a pivotal role in immune responses and certain oncologic conditions. The intense investigation of its biological activity and function led to the discovery of two different IL-6 …
Soluble interleukin-6 receptor in the COVID-19 cytokine storm …
Chen et al. describe the role of soluble interleukin-6 receptor (sIL-6R) in IL-6 trans-signaling and how understanding the IL-6:sIL-6R axis might help define and treat COVID-19 cytokine storm …
Function and proteolytic generation of the soluble interleukin …
Jan 1, 2022 · The pleiotropic cytokine interleukin-6 (IL-6) is involved in numerous physiological and pathophysiological functions that include development, immune cell differentiation, …
The soluble Interleukin 6 receptor: Generation and role
Jun 1, 2011 · The Interleukin 6 receptor (IL-6R) is found as a transmembrane protein on hepatocytes and subsets of leukocytes, but soluble isoforms of the IL-6R (sIL-6R) are …
In addition to the membrane-bound receptor, a soluble form of the IL-6R (sIL-6R) has been purified from human serum and urine (37, 38). This soluble receptor binds IL-6 with an affinity …
The balance of interleukin (IL)-6, IL-6·soluble IL-6 receptor (sIL-6R ...
Interleukin (IL-)6 is the major pro-inflammatory cytokine within the IL-6 family. IL-6 signals via glycoprotein 130 (gp130) and the membrane-bound or soluble IL-6 receptor (IL-6R), referred …