In the presence of oxidative stress, AMPK promotes cytoprotection by enhancing the conservation of energy by suppressing protein translation and by stimulating autophagy. AMPK interplays …

Here, we report that in primary mouse adipocytes, PKA associates with and phosphorylates AMPKα1 at Ser-173 to impede threonine (Thr-172) phosphorylation and thus activation of …

Adenosine monophosphate-activated protein kinase (AMPK) is a conserved, redox-activated master regulator of cell metabolism. In the presence of oxidative stress, AMPK promotes …

PKA and EPAC are the main cAMP effectors and play essential roles in the regulation of a variety of physiological functions. The specificity and selectivity of cAMP signaling is maintained by …

Apr 1, 2021 · Luteinizing hormone (LH) via protein kinase A (PKA) triggers ovulation and formation of the corpus luteum, which arises from the differentiation of follicular granulosa and …

Oct 4, 2017 · AMP-activated protein kinase (AMPK) is a highly conserved sensor of low intracellular ATP levels that is rapidly activated after nearly all mitochondrial stresses, even …

Nov 8, 2019 · To understand the mechanism by which PKA activates mTOR, we began by studying intracellular kinases known to modulate mTOR function. Although AMP-activated …

Adenosine monophosphate-activated protein kinase (AMPK) is a conserved, redox-activated master regulator of cell metabolism. In the presence of oxidative stress, AMPK promotes …

Mar 20, 2014 · Adiponectin activates protein kinase A (PKA), which leads to decreased AKT activity and increased AMP-activated protein kinase (AMPK) activation. AMPK, in turn, …

Jan 17, 2022 · PKA and EPAC are the main cAMP effectors and play essential roles in the regulation of a variety of physiological functions. The specificity and selectivity of cAMP …