CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular …

Cyclic-AMP response element-binding protein (CREB) signaling has a critical role in the formation of memories. CREB signaling is dysfunctional in the brains of mouse models of Alzheimer's …

Aug 2, 2016 · Cyclic-AMP response element-binding protein (CREB) signaling has a critical role in the formation of memories. CREB signaling is dysfunctional in the brains of mouse models of …

CREB is a molecular regulator that plays a crucial role in the growth of dendritic spines and the sprouting of mossy fibers in the brain. It is also involved in the development of epilepsy and is …

In the central nervous system (CNS), CREB is a key modulator of development, plasticity, circadian entrainment, neuroprotection, and resiliency (2). Alterations in CREB-mediated …

Sep 15, 2020 · In this review, we summarize data demonstrating the role of CREB-BDNF signaling pathway in cognitive status and mediation of Aβ toxicity in AD. Finally, we also focus …

Calcium-mediated signaling regulates nuclear gene transcription by calcium/cAMP response element binding protein (CREB) via calcium-dependent kinases and phosphatases. This study …

A lack of biomarkers is one of the major roadblocks in diagnosing the disease and in assessing the efficacy of potential therapies. The phosphorylation of cAMP Response Element Binding …

Mar 3, 2017 · Long known for its role in memory formation –, CREB is activated by phosphorylation at serine133 (pCREB), after which it can dimerize and stimulate transcription …

Upon activation, CREB is phosphorylated (pCREB) at its serine 133 residue, dimerizes with another pCREB, binds its cAMP response element (CRE) site on the DNA via a leucine zipper …