Some of the signalling events involving rsk. In molecular biology, ribosomal s6 kinase (rsk) is a family of protein kinases involved in signal transduction.There are two subfamilies of rsk, p90 rsk, also known as MAPK-activated protein kinase-1 (MAPKAP-K1), and p70 rsk, also known as S6-H1 Kinase or simply S6 Kinase.There are three variants of p90 rsk in humans, rsk 1-3.

Jun 28, 2019 · 核糖体S6激酶（RSK）是参与信号转导的蛋白激酶家族。有两个亚家族rsk，p90rsk，也称为MAPK活化蛋白激酶-1（MAPKAP-K1）和p70rsk，也称为S6-H1激酶或简称S6激酶。 p90rsk在人类中有三种变体，即rsk 1-3。 Rsks是丝氨酸/苏氨酸激酶并且被MAPK / ERK途径激活。

p90RSK, as the downstream effector of the Ras/Raf/MEK/ERK signalling pathway, regulates numerous cell processes including cell growth, proliferation, survival and motility through phosphorylating different substrates and regulating various downstream signalling cascades.

p90RSK在Ras促丝裂原激活的蛋白激酶（MAPK）信号级联中起重要作用，并且是Ras胞外信号调节激酶（ERK1 / 2）信号转导的直接下游效应子。 ERK1 / 2激活直接磷酸化并激活p90RSK，后者又通过选择不同的磷酸化底物来激活各种信号转导事件。

Feb 23, 2019 · The 90 kDa ribosomal s6 kinases (RSKs) are a group of serine/threonine kinases consisting of 4 RSK isoforms (RSK1-4), of which RSK1 is also designated as p90RSK. p90RSK plays an important role in the Ras-mitogen-activated protein kinase (MAPK) signalling cascade and is the direct downstream effector …

Jan 29, 2019 · Itoh and colleagues studied the role of p90RSK in ischemic and diabetic myocardium using transgenic mice with cardiac-specific overexpression of wild-type p90 ribosomal S6 kinase (WT-p90RSK-Tg) and found that recovery of cardiac function after ischemia/reperfusion in isolated hearts from WT-p90RSK-Tg mice is significantly impaired in …

To confirm the role of p90RSK in cTnI phosphorylation in vivo, we generated adenovirus containing a dominant negative form of p90RSK (Ad-DN-p90RSK). We found that the inhibition of p90RSK prevented H 2 O 2 -mediated cTnI (Ser 23/24 ) phosphorylation but not ERK1/2 and PKCα/βII activation.

Dec 19, 2023 · Keywords: RSK; p90 ribosomal S6 kinase; p90RSK; phosphorylation; small molecule inhibitor; substrate.

Association between P90 Ribosomal S6 Kinases Family (RSKs) and Human Diseases

Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J. Biol. Chem. 273:1496-1505. [ DOI ] [ PubMed ] [ Google Scholar ]