Hence, the NF-κB p65 signaling pathway has been a pivotal point for intense drug discovery and development. This review begins with an overview of p65-mediated signaling followed by …

The transcription factors RelA (also known as p65), RelB, c-Rel, p50 and p52 constitute the dimeric transcription factor NF-κB. Theoretically, 15 distinct homo- and heterodimeric NF-κB …

The NAD + -dependent protein deacetylase and longevity factor SIRT1 inhibits NF-κB gene expression by deacetylating the RelA/p65 subunit of NF-κB at lysine 310.

Read about p65 and the NF-κB inflammatory signaling pathway in this review by David Bruce, PhD. The remaining members include RelB, c-Rel, and cleaved proteins NF-κB1 (p50) and NF …

p65 is the NF-κB subunit that has received the most attention in studies of NF-κB phosphorylation so far, and the bulk of the published information is focussed on the two best-understood …

Oct 30, 2018 · This review begins with an overview of p65-mediated signaling followed by discussion of strategies that directly target NF-κB p65 in the context of chronic inflammation.

May 25, 2016 · Vav1 controls downstream p65 phosphorylation and NF-κB activation. Synergistic signalling is defective in X-linked lymphoproliferative disease (XLP1) NK cells entailing 2B4 …

Aug 23, 2016 · Together, our results suggest that Ser (534) phosphorylation of p65 in mice (and, by extension, Ser (536) phosphorylation of human p65) is not required for its nuclear …

The NF-κB p65 (RELA) subunit is a central regulator of innate immunity. Here, we investigated the relative functional contribution of p65 DNA-binding and dimerization in p65-deficient human …

Mar 4, 2024 · In this review, we first scrutinize the research process of NF-κB signaling, and summarize the composition, activation, and regulatory mechanism of NF-κB signaling. We …