Sep 4, 2020 · Upstream of mTORC2 signaling. Besides canonical PI3K-mediated mTORC2 activation, mTORC2 activity is controlled by its localization to different subcellular …

In this review, we focus on recent developments on mammalian mTORC2 signaling mechanisms and its cellular and tissue-specific functions. Key words: mTOR, mTORC2, rictor, cancer, …

Oct 2, 2023 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR …

What might come as a surprise is that mTORC2 signaling is also regulated by mTORC1. This is due to the presence of a negative feedback loop between mTORC1 and insulin/PI3K …

Apr 21, 2009 · mTORC2 promotes the phosphorylation of AGC kinase substrates at two distinct sites. The mammalian target of rapamycin complex 2 (mTORC2) plays critical roles in …

This negative feedback regulation of PI3K and mTORC2 signaling by mTORC1 has numerous implications for the pharmacological targeting of mTOR in disease, discussed below.

Accumulating evidence supports that mTORC2 is activated by GPCR signaling. β- and α-adrenoceptors increase cAMP levels and promote glucose uptake via mTORC2 but are …

In skeletal muscle, β-adrenergic signaling via mTORC2 and mTORC1 promotes protein synthesis and glucose uptake (128). α-Adrenergic signaling to mTORC2 also promotes glucose uptake …

Jan 2, 2019 · In this Review, we introduce the landmark discoveries in the mTOR field, starting from the isolation of rapamycin to the molecular characterizations of key components of the …

Jan 5, 2023 · Here, we review recent advances that describe a role for mTORC2 in this catabolic process, and propose that mTORC2 could be a potential clinical target for the treatment of …