May 2, 2018 · mTOR/S6K1 regulates the SREBP-1c signaling pathway through LXRα in sodium palmitate-induced HepG2 cells, suggesting LXRα might be a potential therapeutic target for NAFLD.

May 18, 2022 · mTOR/S6K1 regulates the SREBP-1c signaling pathway through LXRα in sodium palmitate-induced HepG2 cells, suggesting LXRα might be a potential therapeutic target for NAFLD. Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide.

Oct 12, 2016 · Furthermore, we identified liver X receptor (LXR) as the downstream target of Lamtor1 and mTORC1. Production of 25-hydroxycholesterol is dependent on Lamtor1 and mTORC1. Our findings...

Insulin-mediate activation of mTOR leads to phosphorylation of S6K1, which enhances cleavage of SREBP-1c by activating an unknown target. At the same time, mTOR activates an unknown factor that in turn modulates the LXR/C-EBPβ complex to …

Hence, mTOR signaling may promote foam cell formation and inhibit foam cell egression through suppressing SIRT1-LXR-CCR7 and enhancing NF-κB signaling, while mTOR inhibition or upregulation of SIRT1 signaling may promote foam cell egress and reduce atherosclerotic plaques clinically.

Sep 1, 2016 · Pharmacological or genetic activation of AMPK increased mRNA and protein expression of ABCA1 and its transcriptional activator liver X receptor (LXR) α, resulting in increased cholesterol efflux to apolipoprotein AI-containing medium.

Apr 20, 2012 · This Review focuses on the signalling mechanisms of mTOR in T cell homeostatic and functional fates, and discusses the therapeutic implications of targeting mTOR in T cells.

May 2, 2018 · Conclusions: mTOR/S6K1 regulates the SREBP-1c signaling pathway through LXR α in sodium palmitate-induced HepG2 cells, suggesting LXR α might be a potential therapeutic target for NAFLD ...

Jul 12, 2023 · Adenosine monophosphate-activated protein kinase (AMPK) is a cellular energy sensor and regulator of liver lipid dysfunction and glucose metabolism. The mechanistic target of rapamycin (mTOR) is a protein kinase regulating cell growth, survival, metabolism, and immunity.

Nov 11, 2020 · Here we show that the deubiquitylase ubiquitin-specific peptidase 20 (USP20) stabilizes HMG-CoA reductase (HMGCR), the rate-limiting enzyme in the cholesterol biosynthetic pathway, in the feeding...