In particular, as a core component of both complexes, mTOR functions as a serine/threonine protein kinase that regulates cell growth, cell proliferation, cell motility, cell survival, protein synthesis, autophagy, and transcription.

Extensive research over the past two decades has established a central role for mTOR in regulating many fundamental cell processes, from protein synthesis to autophagy, and deregulated mTOR signaling is implicated in the progression of cancer and diabetes, as well as the aging process.

Target of rapamycin (TOR) is a highly conserved serine/threonine kinase that controls cell growth and metabolism in response to nutrients, growth factors, cellular energy, and stress. TOR, which was originally discovered in yeast, is conserved in all …

Oct 2, 2023 · Here, we provide the detailed structure of mTOR, its complexes, and the comprehensive role of upstream regulators, as well as downstream effectors of mTOR signaling cascades in the metabolism,...

Jan 2, 2019 · Mechanistic target of rapamycin (mTOR) controls cell growth mainly by promoting anabolic processes, including protein, lipid and nucleotide synthesis, and by suppressing catabolic...

In this review, we discuss recent progress in our understanding of mTOR signaling in stem and progenitor cells, highlighting the role of mTOR in the self-renewal, differentiation, proliferation and fate determination of various human and mouse stem cell populations.

In this review, we discuss the role of mTOR in regulating metabolism and how these pathways intersect with the ability of mTOR to integrate cues that guide the outcome of T-cell receptor engagement. Keywords: T cells, T-helper cells, cell activation, cell differentiation, anergy.

Apr 20, 2012 · Antigen recognition triggers robust mTOR activation, which drives the differentiation of naive CD4 + T cells into the T helper 1 (T H 1), T H 2 and T H 17 cell effector lineages, while...

The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration.

In mammals, mTOR is stimulated by nutrients and growth factors and inhibited by stress to ensure that cells grow only during favorable conditions. Studies in different organisms have reported localization of TOR to several distinct subcellular compartments.