mRNA m6A detection - Nature Reviews Methods Primers
Dec 12, 2024 · N6-methyladenosine (m6A) is an mRNA modification influencing gene expression. Advanced methodologies for mapping m6A enhance understanding of its dynamic roles and …
The role of m6A modification in the biological functions and
Feb 21, 2021 · Recent studies have shown that m6A RNA modification plays essential role in both physiological and pathological conditions, especially in the initiation and progression of …
Reading, writing and erasing mRNA methylation - Nature
Sep 13, 2019 · These maps have revealed the specific mRNAs that are regulated by m 6 A, providing mechanistic links connecting m 6 A to cellular differentiation, cancer progression and …
m 6 A RNA methylation: from mechanisms to therapeutic potential …
Feb 1, 2021 · We highlight advances in our understanding of the regulation of m 6 A deposition on mRNA and its context-dependent effects on mRNA decay and translation, the role of m 6 A …
mRNA m6A regulates gene expression via H3K4me3 shift in 5’ …
Mar 12, 2025 · We demonstrate that m6A methylation in the 5’ UTR of mRNA triggers a downstream shift in H3K4me3 modification. This regulatory mechanism is conserved in …
m6A RNA methylation: from mechanisms to therapeutic potential
We highlight advances in our understanding of the regulation of m 6 A deposition on mRNA and its context‐dependent effects on mRNA decay and translation, the role of m 6 A methylation of …
Exon architecture controls mRNA m6A suppression and gene
Jan 27, 2023 · We identify exon junction complexes (EJCs) as m 6 A suppressors that protect exon junction–proximal RNA within coding sequences from methylation and regulate mRNA …
RNA m6A methylation across the transcriptome - Cell Press
Feb 2, 2023 · Here, we review RNA m6A modification in the light of the recent appreciation of nuclear roles for m6A in regulating chromatin states and gene expression, as well as the …
Dynamic regulation and functions of mRNA m6A modification
Jan 29, 2022 · Here, we review the general role of m6A, highlighting recent advances related to the three major types enzymes that determine the level of m6A modification (i.e., writers, …
The detection and functions of RNA modification m6A based on m6A …
N6-methyladenosine (m6A) is the most frequent chemical modification in eukaryotic mRNA and is known to participate in a variety of physiological processes, including cancer progression and …