Jun 24, 2024 · Here, we report that KRAS G12V is a good neoantigen candidate for people with the HLA-A*11:01 type, and combined therapy with a single neoantigen mRNA vaccine …

Feb 1, 2024 · The new vaccine is able to activate immune cells that target different KRAS mutations called KRAS-G12D and KRAS-G12R, which drive about 90% of pancreatic cancers and 40% of colon cancers. The vaccine contains synthesized peptides (short chains of amino acids) that can launch immune cells to target cancer cells with these mutations.

A lipid nanoparticle (LNP)-formulated mRNA-based cancer vaccine that targets four of the most commonly occurring KRAS mutations (G12D, G12V, G13D, and G12C), with potential immunostimulatory and antineoplastic activities.

Feb 24, 2022 · Merck has dumped Moderna’s mutant KRAS vaccine mRNA-5671. The action, which comes shortly after Merck closed enrollment in a phase 1 trial, leaves Moderna pondering the next steps for the...

Apr 4, 2023 · We designed a Pan-Ras neoantigen mRNA vaccine (mRNA-1521), which covers all prevalent RAS mutations to achieve broad-spectrum cancer therapy. We synthesized a multiepitope neoantigen KRAS mRNA vaccine (mRNA-1521) and examined its immune response and anti-tumor efficacy in the colon cancer of Balb/c mice.

Lastly, the mRNA-5671 cancer vaccine for KRAS G12C, G12D, G13D and G12V is currently being tested in a phase I study as a monotherapy as well as with the PD1 inhibitor pembrolizumab in advanced or metastatic KRAS mutant NSCLC, colorectal and pancreatic cancer patients with an estimated study completion date being end of 2026 (Clinicaltrials.gov ...

mRNA-5671 also known as V941 is a cancer vaccine candidate developed by Moderna. [1] It is a tetravalent vaccine that targets G12D, G12V, G13D or G12C driver mutations in the KRAS gene. [2]

Apr 14, 2023 · Multi-targeting of different KRAS mutations can prevent resistance due to the heterogeneity of KRAS mutations within a tumor. To achieve this, we incorporated an mRNA-based cancer vaccine containing transcripts for multiple KRAS mutant antigens.

Jan 9, 2024 · Cancer vaccine ELI-002 2P enhances lymph node delivery and immune response using amphiphile (Amph) modification of G12D and G12R mutant KRAS (mKRAS) peptides (Amph-Peptides-2P) together...

Neo-antigens encoded by KRAS mutations have been identified as tumor-specific with high immunogenicity and can be used to deliver precision cancer vaccines to promote anti-tumor immune responses. KRAS mutation-based cancer vaccines have produced encouraging preclinical and clinical results.