There are minor pathways of decay for certain mRNAs. These include pathways initiated by deadenylation-independent decapping and endoribonucleolytic cleavage. There are several surveillance...

Mar 28, 2024 · Applying RIDR to endogenous ACTB mRNA reveals rapid formation and dissolution of RNA granules in pre-existing P-bodies. Time-resolved RNA distribution measurements demonstrate rapid RNA decay...

Jan 27, 2025 · Recent advances in structural, single-molecule and genome-wide methods have provided new insights into the central machineries that carry out mRNA turnover, the mechanisms by which mRNAs are...

The life of an mRNA molecule begins with transcription and ultimately ends in degradation. In the course of its life, however, mRNA is examined, modified in various ways and transported before eventually being translated into proteins.

Nonsense-mediated mRNA decay (NMD) is a surveillance pathway that exists in all eukaryotes. Its main function is to reduce errors in gene expression by eliminating mRNA transcripts that contain premature stop codons. [1] .

This review illustrates ways in which mRNA decay endows cells with effective responses to changing milieus, and provides some examples of how disregulation of mRNA decay can impact disease-associated processes.

Jan 24, 2025 · Using human and mouse cells, we show that tristetraprolin (TTP, also known as ZFP36), an essential anti-inflammatory RBP, destabilizes target mRNAs via a hierarchical molecular assembly. The assembly formation strictly relies on the interaction of TTP with RNA.

This chapter discusses several topics relating to the mechanisms of mRNA decay. These topics include the following: important physical properties of mRNA molecules that can alter their stability; methods for determining mRNA half-lives; the genetics and biochemistry of proteins and enzymes involved …

This review examines cytoplasmic mRNA decay with a focus on how mRNA decay regulates transcript abundance. Typically, changes in RNA abundances are attributed to transcription; however, considerable evidence supports important contributions from mRNA decay and this review focuses on recent advances in this area.

Jan 11, 2025 · Explore the intricate processes of RNA decay and its crucial roles in gene regulation, stress response, and disease associations. RNA decay is a cellular process that maintains the balance of RNA molecules within cells, influencing gene expression and overall cellular function.