Here we discuss current insights into the molecular mechanisms by which CREB couples synaptic activity to long-term changes in neuronal plasticity, which is thought to underlie learning and …

Here, we have elucidated the molecular mechanisms behind TrkB signaling-dependent BDNF mRNA induction and show that CREB family transcription factors are the main regulators of …

Upregulation of BDNF mRNA expression is parallel to increased phosphorylated CREB expression (Guo et al., 2017), and inhibition of PKA/CREB pathway attenuates the level of …

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene. [5] [6] This protein binds the cAMP response element, a DNA …

Aug 6, 2024 · An alternatively spliced polycistronic mRNA encoding cyclic adenosine 3′,5′-monophosphate (cAMP)-responsive transcription factor CREB (cAMP response element …

Aug 15, 2002 · In this review, we highlight the function and regulation of CREB family transcription factors as key mediators of stimulus-induced nuclear responses that underlie the …

Feb 1, 2024 · By using chromatin immunoprecipitation and genomic footprinting assays to determine gene promoter occupancy by CREB, combined with mRNA expression analysis, …

CREB is a stimulus-induced bZIP transcription factor that is activated by phosphorylation at its Ser 133 site. Phosphorylated CREB (pCREB) dimerizes and binds to cAMP response element …

Apr 28, 2020 · Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is …

Mar 3, 1996 · The new isoform, termed CREB beta, has nearly the same transactivation potential as the other CREB isoforms and is expressed ubiquitously. The up-regulation appears to be …