Feb 14, 2024 · The role of m6A modification associated with lncRNA in tumorigenesis and tumor suppression is being gradually explored by scientists. m6A modifications can induce structural changes in...

New roles for RNA in mediating gene expression are being discovered at an alarming rate. A broad array of pathways control patterning of N6-methyladenosine (m6A) methylation on RNA transcripts. This review comprehensively discusses long non-coding ...

May 9, 2022 · In this review, we overview the current status of m6A and lncRNAs based on the latest research, and propose some viewpoints for future research perspectives.

Aug 13, 2020 · Here, we show that the internal m6A modification of the lncRNA THOR via an m6A-reader-dependent modality regulates the proliferation of cancer cells. Our findings demonstrated that the loss...

Dec 1, 2020 · N6-methyladenosine (m6A), which is the most abundant modification in eukaryotic mRNAs, was discovered by Ronald et al in 1974. 12 M6A modification exerts multiple functions on mRNA and lncRNA, as it regulates mRNA splicing, stability, nuclear export, and translation.

Nov 22, 2019 · In glioblastoma stem cells (GSCs), an m6A demethylase, ALKBH5, was shown to interact with the lncRNA Forkhead box protein M1 (FOXM1)-AS to promote cancer cell proliferation and tumorigenicity. ALKBH5 can induce high levels of FOXM1 transcripts by demethylating FOXM1 nascent transcripts.

Mar 31, 2025 · Background N6-methyladenosine (m6A) and ferroptosis are involved in the development and prognosis of various cancers via long noncoding RNAs (lncRNAs). This study aimed to investigate the cervical cancer subtypes based on m6A-and ferroptosis-related lncRNAs (mfrlncRNAs) and to construct a mfrlncRNA signature to predict cervical cancer prognosis and treatment response. Methods mfrlncRNA-related ...

Mar 11, 2025 · This study aimed to evaluate the function of lncRNA LINC00968 in gastric cancer biological processes, and we discovered the role of KIAA1429, a typical m6A eraser, in mediating LINC00968 function. The expression of LINC00968 was assessed using PCR and regulated by cell transfection.

Apr 9, 2025 · Recently, a few studies indicated that KHSRP could also stabilize some mRNAs as an N6-methyladenosine (m6A)–binding protein and blocks mRNA degradation from nuclear exoribonuclease XRN2 (48, 49). We performed immunofluorescence (IF) staining in C4-2 cells, showing that KHSRP protein was predominantly located in the cell nucleus (fig. S5H ...

Nov 14, 2023 · Transcriptome‐wide mapping technology reveals a significant presence of m6A‐modified lncRNA, which has been shown to play vital roles in biological processes. Interestingly, the expressions and functions of m6A modification are also regulated by lncRNA in …