Mar 30, 2025 · The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis).

Mar 30, 2025 · The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system.

Mar 30, 2025 · Complete information for IL10 gene (Protein Coding), Interleukin 10, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium

Mar 30, 2025 · Protein structure modeling indicated that this cytokine may contain a 12-stranded beta-trefoil structure that is conserved between IL1A (IL-A alpha) and IL1B (IL-1 beta). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2.

Mar 30, 2025 · This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections.

Mar 28, 2025 · GeneCards is a searchable, integrative database that provides comprehensive, user-friendly information on all annotated and predicted human genes. The knowledgebase automatically integrates gene-centric data from ~200 web sources, including genomic, transcriptomic, proteomic, genetic, clinical and functional information.

Mar 30, 2025 · IL1A (Interleukin 1 Alpha) is a Protein Coding gene. Diseases associated with IL1A include Keratoconjunctivitis Sicca and Silicosis. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and interleukin-1 receptor binding.

Mar 30, 2025 · IL4 (Interleukin 4) is a Protein Coding gene. Diseases associated with IL4 include Schistosomiasis and Allergic Disease. Among its related pathways are MIF Mediated Glucocorticoid Regulation and TGF-Beta Pathway. Gene Ontology (GO) annotations related to this gene include cytokine activity and cytokine receptor binding.

Symbol Description Category UniProt ID GIFtS GC id Score; 1: CXCL8: C-X-C Motif Chemokine Ligand 8: Protein Coding: P10145: 57: GC04P073740: 30.22: 2: CXCR2: C-X-C Motif Chemokine Receptor 2

Mar 30, 2025 · Complete information for IL17A gene (Protein Coding), Interleukin 17A, including: function, proteins, disorders, pathways, orthologs, and expression. GeneCards - The Human Gene Compendium