Dec 6, 2022 · Despite their distinct development and mechanism of antigen recognition, iNKT cells mirror MHC-restricted helper T cells and are composed of distinct subsets that resemble the conventional...

Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen -presenting molecule that binds self and foreign lipids and glycolipids.

iNKT cells are a heterogenous population of T cells that express NK cell markers, as well as a TCR [21,22]. These NK cell markers include CD161 and CD56 in humans, and NK1.1 and DX5 in mice [21,22].

Jan 21, 2013 · Invariant natural killer T (iNKT) cells are a specialized subset of T cells that use their T cell receptors (TCRs) to recognize self and foreign lipids presented by CD1d as cognate antigens.

Invariant natural killer T cells (iNKT cells) are an innate-like T cell subset that expresses an invariant T cell receptor (TCR) α-chain and recognizes lipids presented on CD1d. They secrete diverse cytokines and can influence many types of immune responses.

Invariant natural killer T (iNKT) cells are a CD1d-restricted T cell population that can respond to lipid antigenic stimulation within minutes by secreting a wide variety of cytokines. This broad functional scope has placed iNKT cells at the frontlines of many kinds of immune responses.

In this review, we discuss the latest findings in iNKT cell development, focusing in particular on how T-cell receptor signal strength steers iNKT cell progenitors toward specific subsets and how early progenitor cells can be identified.

Invariant natural killer T (i NKT) cells, also known as type I or classical NKT cells, are a distinct population of T cells that express an invariant aβ T-cell receptor (TCR) and a number of cell surface molecules in common with natural killer (NK) cells.

Mar 12, 2025 · iNKT cells bridge innate and adaptive immunity, influencing immune responses through diverse subsets, activation mechanisms, and interactions with other cells.

May 31, 2022 · Recent unbiased single-cell RNA sequencing of mouse invariant natural killer T (iNKT) cells revealed previously unappreciated heterogeneity. iNKT2 cell transcriptomes reveal RNA plasticity indicative of multipotency, and iNKT2 cells …