Telomerase reverse transcriptase (abbreviated to TERT, or hTERT in humans) is a catalytic subunit of the enzyme telomerase, which, together with the telomerase RNA component …

Human telomerase reverse transcriptase (hTERT)–immortalized primary cells represent a breakthrough in cell biology research that combines the in vivo nature of primary cells with the …

Telomerase exerts its DNA polymerizing function through the formation of a complex consisting of two main subunits: the catalytic protein hTERT and the human telomerase RNA component …

Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. Transcriptional regulation of hTERT is …

Jan 26, 2024 · Telomerase reverse transcriptase (TERT) is a key component of telomerase. Human TERT was first cloned in 1997 [5, 8, 9, 10], eight years after telomerase was first …

Background: Human telomerase reverse transcriptase (hTERT) is a catalytic enzyme that is required for telomerase activity (TA) and cancer progression. Telomerase inhibition or …

The results showed that siRNA targeting hTERT could effectively knock down hTERT expression, remarkably suppress telomerase activity, cell proliferation, migration and invasion, and …

Jun 8, 2020 · Human telomerase reverse transcriptase (hTERT) is a catalytic subunit of telomerase that functions in telomere maintenance as well as several non-telomeric activities. …

Mar 12, 2018 · Background: Limitless self-renewal is one of the hallmarks of cancer and is attained by telomere maintenance, essentially through telomerase (hTERT) activation. …

Human telomerase reverse transcriptase (hTERT) is a major component of telomerase activity. We show here that hTERT is expressed soon after lymphocyte activation and that its …