Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene. [5] eIF4B has been shown to interact with and stimulate the activity of eIF4A and bind to the eIF3 complex through the eIF3A subunit. [6] .

Mar 28, 2025 · EIF4B (Eukaryotic Translation Initiation Factor 4B) is a Protein Coding gene. Diseases associated with EIF4B include Mouth Disease and Schinzel-Giedion Midface Retraction Syndrome. Among its related pathways are Peptide chain elongation and Translation Insulin regulation of translation.

Yeast eIF4B (Tif3) consists of an N-terminal domain, followed by a domain with seven repeat regions, an RNA recognition motif and a C-terminal domain (Figure 1C). eIF4B stimulates RNA unwinding by eIF4A without affecting its ATPase activity (13, 26, 31–32).

Jan 29, 2024 · The structure identifies the interaction of eIF4B with the entry site bound eIF4A, providing insight into its role in regulating this second eIF4A rather than eIF4F during scanning.

Sep 8, 2024 · Title: eIF4B enhances ATF4 expression and contributes to cellular adaptation to asparagine limitation in BRAF-mutated A375 melanoma. Long noncoding RNA GMAN promotes hepatocellular carcinoma progression by interacting with eIF4B.

Oct 10, 2024 · This study reveals how the intrinsically disordered region of eIF4B governs its transition from monomers to oligomers and condensed droplets, providing key insights into how its self-association...

eIF4B is the RSK downstream effector responsible for elevated Lamgamma2 as well as MYC protein in neoplastic epithelial cells. The protein level of eukaryotic translation initiation factor 4B (eIF4B) was dramatically reduced in A549 cells as well as in the lung, spleen, and thymus of mice infected with influenza A virus.

Oct 10, 2010 · In this review we will analyze the bulk of data describing eIF4B and its role in cell survival and proliferation. Recent studies have shown that eIF4B is phosphorylated and activated by Ras-MAPK and PI3K-mTOR signaling cascades. In addition, eIF4B regulates translation of proliferative and pro-survival mRNAs.

Sep 3, 2024 · eIF4B regulates the stability of replication-dependent histone mRNAs and contributes to S-phase progression. The consequences of eIF4B binding to its target mRNAs include that it directly controls protein levels by stimulating mRNA translation or that it controls protein expression indirectly through regulating mRNA stability and turnover.

The translation initiation factors eIF4B and eIF4G accelerate the eIF4A conformational cycle. eIF4G increases the rate of closing more than the opening rate, and eIF4B selectively increases the closing rate.