Regulation of EGFR endocytic trafficking by rab proteins
The endocytic pathway regulates the rate of EGFR degradation and recycling, as well as the signaling mediated by the EGFR. In this review, the role of rabs, a family of small molecular …
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR
Nov 7, 2022 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for …
Role of rab5 in EGF receptor-mediated signal transduction
In this study, we demonstrate that overexpression of both dominant negative Rab5 (Rab5:S34N) and full-length Rin1 selectively block EGF activation of the Raf-Erk1/2 kinase pathway and …
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR
Nov 7, 2022 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for …
Rab5 Isoforms Differentially Regulate the Trafficking and …
Ligand-mediated endocytosis is an intricate regulatory mechanism for epidermal growth factor receptor (EGFR) signal transduction. Coordinated trafficking of EGFR ensures its temporal …
Rab GTPases as regulators of endocytosis, targets of disease and ...
For example, epidermal growth factor receptor (EGFR) signaling through Ras increases the activity of Rin1 whose guanine nucleotide exchange factor (GEF) activity causes Rab5 …
Rab8 and Rabin8-Mediated Tumor Formation by Hyperactivated EGFR …
Oct 20, 2020 · We demonstrate that RABN-8, an ortholog of Rabin8, known as a GEF for Rab8, is also required for Muv formation by promoting the secretion of EGL-17/FGF from vulval …
Rab21 attenuates EGF-mediated MAPK signaling through enhancing EGFR …
May 18, 2012 · Using a transient expression protocol in HEK293T and HeLa cells, we found that Rab21 enhanced the degradation of EGFR through accelerating its internalization in both EGF …
The clathrin adaptor complex-1 and Rab12 regulate post-golgi ...
May 25, 2022 · We demonstrate that AP-1 and Rab12 are important for epidermal growth factor–induced phosphorylation of EGFR, cell elongation, and proliferation, suggesting that AP …
Interrelation among TLR4, EGFR and Rab Proteins Induced by …
Jul 20, 2020 · In this article, we review the literature on the mechanism underlying the cross-talk between TLR4 and EGFR signaling, with special emphasis on summarizing the research …