Human epidermal growth factor receptor 2 (HER2), a targetable transmembrane glycoprotein receptor of the epidermal growth factor receptor (EGFR) family, plays a crucial role in cell proliferation, survival, and differentiation.

Activated EGFR can also be internalized in endosomes to be degraded via lysosome-mediated degradation pathway, recycled to the cell surface via receptor recycling pathway, or translocated to other subcellular compartments, e.g., the nucleus and mitochondria (7, 24, 64).

Feb 6, 2025 · Explore the structural nuances of EGFR HER2 and their roles in signaling pathways influencing cell proliferation and cancer development.

Epidermal growth factor receptor (EGFR) signaling pathways leading to G1/S cell cycle progression activated by EGF activation. Depicted are the RAS-RAF-MEK-ERK MAPK and PI3K-AKT-mTOR pathways. EGF activation of the EGFR induces receptor dimerization and transphosphorylation of the C-terminal domain.

On the basis of preclinical and clinical evidence, EGFR, HER2 and VEGF represent validated targets for cancer therapy and remain the subject of intensive investigation. Both EGFR and HER2 are targets found on cancer cells, whereas VEGF is a target that acts in the tumour microenvironment.

Feb 13, 2023 · Here, we report the cryo-EM structures of the EGFR/HER2 ectodomain complex with two EGFR ligands — epidermal growth factor (EGF) and epiregulin (EREG) — at resolutions of 3.3 Å and 4.5 Å,...

The epidermal growth factor receptor (EGFR) family, comprising receptor tyrosine kinases (RTK) such as EGFR and HER2, plays a critical role in various signaling pathways related to cell proliferation, differentiation, and growth. EGFR overactivation due to aberrant signaling can lead to various cancers, including non-small cell lung cancer (NSCLC).

Dec 3, 2023 · Activated EGFRs stimulate multiple downstream signal transduction pathways. For example, tyrosine phosphorylation of EGFR creates binding sites for adaptor protein, Grb2 and Src homology 2 (SHC2), which activate the Ras/Raf/MAPK pathway through the Son of Sevenless (SOS) protein, leading to cell proliferation.

Sep 14, 2012 · On the basis of preclinical and clinical evidence, EGFR, HER2 and VEGF represent validated targets for cancer therapy and remain the subject of intensive investigation. Both EGFR and HER2 are targets found on cancer cells, whereas VEGF is a target that acts in the tumour microenvironment.

HER2 as well as the other members of the EGFR family are receptor tyrosine kinases which are located on the cell membrane and responds to a wide variety of ligands. Phosphorylation of the...