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plos.org
https://journals.plos.org › plosone › article
Functional cycle of EEA1-positive early endosome: …
May 1, 2020 · EEA1-vesicles directly fuse with incoming EGF/EGFR-vesicles into hybrid endosomes with separated EEA1- and EGFR-domains, thus providing …
Author: Rimma Kamentseva, Vera Kosheverova, Marianna Kharchenko, Maria Zlobina, Anna Salova, Tatiana Belyaev...
Publish Year: 2020
Images of EGFR EEA1

bing.com › images
molbiolcell.org
Gαs promotes EEA1 endosome maturation and shuts down proliferative ...
researchgate.net
Loss of RAB7 does not affect EGFR progression through EEA1 positive ...
researchgate.net
EGFR colocalization with EEA1 is prolonged and degradation is inhibited ...
researchgate.net
The active form of EGFR localizes to EEA1-positive endosomes. (A and C ...
researchgate.net
EGFR colocalization with EEA1 is prolonged and degradation is inhibited ...
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nih.gov
https://pmc.ncbi.nlm.nih.gov › articles
ESCRT-0 marks an APPL1-independent transit route for EGFR …
RNA silencing experiments show that both ESCRT-0 and ESCRT-I are important for the transit of EGF to EEA1 endosomes. The epidermal growth factor receptor (EGFR) pathway serves as …
- PMC Free Article
EMBO Press
https://www.embopress.org › doi › full
Targeting of early endosomes by autophagy facilitates …
Aug 26, 2019 · Cells lacking ATG 7 or ATG 16L1 exhibit increased levels of phosphatidylinositol‐3‐phosphate (PI (3)P), a key determinant of early …
Author: Jane Fraser, Joanne Simpson, Rosa Fontana, Chieko Kishi-Itakura, Nicholas T Ktistakis, Noor Gammoh
Publish Year: 2019
Studies of eGFR EEA1
National Center for Biotechnology Information
Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin)
EEA1 endosomes are believed to function mainly in down-regulating EGFR signaling, and APPL endosomes are regarded as signaling endosomes. Evidence is given that EGF-induced, proliferative signaling occurs from EEA1 endosomes and is regulated by interaction between the signal-transducing protein GIV ...
Author: Anthony O. Be…
Published: 2012/12/12
Publication: Mol Biol C…
PubMed
Gαs promotes EEA1 endosome maturation and shuts down proliferative signaling through interaction with GIV (Girdin)
The organization of the endocytic system into biochemically distinct subcompartments allows for spatial and temporal control of the strength and duration of signaling. Recent work has established that Akt cell survival signaling via the epidermal growth factor receptor (EGFR) occurs from APPL early ...
Author: Anthony O Beas
Published: 2012/12
Keywords: National In…
ResearchGate
Functional cycle of EEA1-positive early endosome: Direct evidence for pre-existing compartment of degradative pathway
Early endosomes, regarded as the main sorting station on endocytic pathway, are characterized by high frequency of homotypic fusions mediated by tethering protein EEA1. Despite intensive investigations, biogenesis of endosomes, boundaries between early and late endosomes, and process of cargo transi...
Published: 2020/05/01
DOI: 10.1371/journal.p…
National Center for Biotechnology Information
Piezo1 activates noncanonical EGFR endocytosis and signaling
EGFR-ERK signaling controls cell cycle progression during development, homeostasis, and disease. While EGF ligand and mechanical inputs can activate EGFR-ERK signaling, the molecules linking mechanical force to this axis have remained mysterious. We previously found that stretch promotes mitosis via...
Author: Carlos Pardo-…
Published: 2023/09/09
Publication: Sci Adv. 2…
PubMed
Functional cycle of EEA1-positive early endosome: Direct evidence for pre-existing compartment of degradative pathway
Early endosomes, regarded as the main sorting station on endocytic pathway, are characterized by high frequency of homotypic fusions mediated by tethering protein EEA1. Despite intensive investigations, biogenesis of endosomes, boundaries between early and late endosomes, and process of cargo transi...
Author: Rimma Kamen…
Published: 2020/05/01
Keywords: National In…
PubMed
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis
EGFR phosphorylation is required for TLR4-mediated macrophage activation during sepsis. However, whether and how intracellular EGFR is transported during endotoxemia have largely been unknown. Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two diff...
Author: Xuedi Zhang
Published: 2022/11/07
Keywords: National In…
Nature
https://www.nature.com › articles
EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR
Nov 7, 2022 · Here, we show that LPS promotes high levels cell surface expression of EGFR in macrophages through two different transport mechanisms. On one hand, Rab10 is required for …
PNAS
https://www.pnas.org › doi
O-GlcNAcylation regulates epidermal growth factor …
We analyzed the coimmunostaining of EGFR with early endosomal antigen 1 (EEA1), a cellular marker for early endosomes, after 30 min of EGF stimulation. In cells expressing WT or 3SA HGS, EGFR was colocalized with EEA1 at …
National Center for Biotechnology Information
https://www.ncbi.nlm.nih.gov › pmc › articles
Gαs promotes EEA1 endosome maturation and shuts down …
Dec 1, 2012 · Our present findings establish that EEA1 endosomes are the site of the Gαs effect on EGFR trafficking and that Gαs and GIV functionally interact to facilitate endosome …
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Does EGFR colocalize with EEA1?
When stimulated with EGF, the receptor was efficiently internalized within 10 min into early endosomes containing EEA1 in mock-treated controls (Fig. 6A). Unbiased automated quantification with CellProfiler software showed that the bulk of endocytosed EGFR colocalized with EEA1 (fig. S8A).
Regulation of the EGF Transcriptional Response by Endocytic Sorting
science.org
Does EGF stimulate EEA1?
Data in (C) and (D) are normalized to the peak value of control cells. When stimulated with EGF, the receptor was efficiently internalized within 10 min into early endosomes containing EEA1 in mock-treated controls (Fig. 6A).
Regulation of the EGF Transcriptional Response by Endocytic Sorting
science.org
How is EGFR internalization reduced in eea1-containing endosomes?
Because EGFR internalization into EEA1-containing endosomes was reduced by double knockdown of clathrin heavy chain and dynamin 2 or CBL and CBLB (Fig. 6, B and C, and fig. S8A), we quantified the receptor present at the plasma membrane in the absence of permeabilization.
Regulation of the EGF Transcriptional Response by Endocytic Sorting
science.org
Can EEA1 be substituted for Rab5 in EGFR-containing endosomes?
According to maturation hypothesis, such Rab5 effector as EEA1 should be recruited onto newly formed EGFR-containing endosomes from cytoplasm and at some maturation stage dissociates back, being substituted by Rab7, master of late endosomal events.
Functional cycle of EEA1-positive early endosome: Direct ... - PLOS
journals.plos.org
How is EEA1 and LAMP1 localised during EGFR endocytosis?
The localisation of EEA1 and Lamp1 during EGFR endocytosis. Endocytosis in HeLa cells was stimulated according to pulse-chase protocol by adding of EGF-Cy3 (red channel) for 5 min followed by washout of unbound ligand and chase period at 37°C. Cells were fixed and immunostained using antibodies against EEA1 (green channel) and Lamp1 (blue channel).
Functional cycle of EEA1-positive early endosome: Direct ... - PLOS
journals.plos.org
How does EGFR work?
The activated EGFR is rapidly internalized through the clathrin-dependent mechanism, and targeted to early endosomes, where EGFR signaling persists. A population of EGFR molecules recycles back to the plasma membrane, while the remaining EGFR molecules are sorted into intraluminal vesicles (ILVs) of the multivesicular body (MVB).
O-GlcNAcylation regulates epidermal growth factor receptor
pnas.org
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PubMed
https://pubmed.ncbi.nlm.nih.gov
Gαs promotes EEA1 endosome maturation and shuts down
Our findings define EEA1 endosomes as major sites for proliferative signaling and establish that Gαs and GIV regulate EEA1 but not APPL endosome maturation and determine the duration …
ResearchGate
https://www.researchgate.net › publication
(PDF) Functional cycle of EEA1-positive early …
May 1, 2020 · Here, using EGF/EGFR endocytosis as a model and confocal microscopy of fixed and live cells, we provide evidence favoring EEA1-vesicles being pre-existed vesicular compartment, that maintains its...
eLife
https://elifesciences.org › articles
Regulation of EGFR signal transduction by analogue-to …
Feb 4, 2015 · The model was fitted to the experimental data which included time courses of p-EGFR and EGFR colocalization to EEA1 (Kalaidzidis et al., 2015) upon stimulation with four different concentrations (0.5, 1.0, 5.0, and 10.0 …
Science | AAAS
https://www.science.org › doi
Regulation of the EGF Transcriptional Response by …
Unbiased automated quantification with CellProfiler software showed that the bulk of endocytosed EGFR colocalized with EEA1 (fig. S8A). Depletion of clathrin heavy chain or dynamin 2 inhibited the appearance of EGFR into EEA1 …
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Functional cycle of EEA1-positive early endosome: …

Images of EGFR EEA1

ESCRT-0 marks an APPL1-independent transit route for EGFR …

Targeting of early endosomes by autophagy facilitates …

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR

O-GlcNAcylation regulates epidermal growth factor …

Gαs promotes EEA1 endosome maturation and shuts down …

Regulation of the EGF Transcriptional Response by Endocytic Sorting

Regulation of the EGF Transcriptional Response by Endocytic Sorting

Regulation of the EGF Transcriptional Response by Endocytic Sorting

Functional cycle of EEA1-positive early endosome: Direct ... - PLOS

Functional cycle of EEA1-positive early endosome: Direct ... - PLOS

O-GlcNAcylation regulates epidermal growth factor receptor

Gαs promotes EEA1 endosome maturation and shuts down

(PDF) Functional cycle of EEA1-positive early …

Regulation of EGFR signal transduction by analogue-to …

Regulation of the EGF Transcriptional Response by …

Related searches for eGFR EEA1

Related searches for eGFR EEA1