- Copilot AnswerDiscovery
The E-box was discovered in a collaboration between Susumu Tonegawa's and Walter Gilbert's laboratories in 1985 as a control element in immunoglobulin heavy-chain enhancer. They found that a region of 140 … See more
Watch full videoBindingE-box binding proteins play a major role in regulating transcriptional activity. These proteins usually contain the basic helix-loop-helix protein structural motif, which allows them to bind as dimers. This motif consists of two … See more
E-box independent chromatin recruitment turns MYOD into a ...
Dec 5, 2024 · MYOD is an E-box sequence-specific basic Helix-Loop-Helix (bHLH) transcriptional activator that, when expressed in non-muscle cells, induces nuclear reprogramming toward …
A non-canonical E-box within the MyoD core enhancer is …
Dec 30, 2011 · We identify a previously unknown non-canonical E-box in the MyoD CE that mediates CLOCK and BMAL1 binding and using an in vitro circadian assay we demonstrate …
- Author: Xiping Zhang, Samir P. Patel, John J. McCarthy, Alexander G. Rabchevsky, David J. Goldhamer, Karyn A...
- DOI: 10.1093/nar/gkr1297
- Publish Year: 2012
- Published: 2012/04
MyoD uses overlapping but distinct elements to bind E-box and …
In this work, we identified elements in MyoD that bind E-box or tetraplex structures of promoter sequences of the muscle-specific genes α7 integrin and sarcomeric Mitochondrial Creatine …
MyoD is a 3D genome structure organizer for muscle cell identity
Jan 11, 2022 · We show that MyoD functions as a “genome organizer” that specifies 3D genome architecture unique to muscle cell development, and that H3K27ac is insufficient for the …
Genome-wide MyoD Binding in Skeletal Muscle Cells: …
Apr 20, 2010 · The consensus E-box motif is present in 96% of the MyoD-binding regions, and, as predicted from previous in vitro degenerate binding site selections, there is a preference for E-boxes with internal CC or GC …
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In this work, we identified elements in MyoD that bind E-box or tetraplex structures of promoter sequences of the muscle-specific genes a7 integrin and sarcomeric Mitochondrial Creatine …
MyoD uses overlapping but distinct elements to bind E-box and
In this work, we identified elements in MyoD that bind E-box or tetraplex structures of promoter sequences of the muscle-specific genes alpha7 integrin and sarcomeric Mitochondrial …
MyoD uses overlapping but distinct elements to bind E …
Oct 16, 2007 · Muscle differentiation and expression of muscle-specific proteins are initiated by the binding of heterodimers of the transcription factor MyoD with E2A proteins to E-box motif d (CANNTG) in promoters or enhancers of muscle …
A non-canonical E-box within the MyoD core enhancer is
In this study, we provide in vivo and in vitro evidence that the CE is necessary for circadian expression of MyoD in adult muscle. Gel shift assays identified a conserved non-canonical E …
