Jan 28, 2019 · THZ1, a recently identified covalent CDK7 inhibitor, has shown a high potency against multiple cancers through targeting transcriptional addictions. The high ranking of THZ1 …

Jul 20, 2020 · CDK7 silencing and CDK7 inhibitor THZ1 elicited apoptosis and suppressed tumor growth. Moreover, CDK7 ablation specifically suppressed p38α/MYC-associated genes, and …

Jun 22, 2014 · Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside …

Jul 31, 2014 · Here we present the discovery and characterization of a covalent CDK7 inhibitor, THZ1, which has the unprecedented ability to target a remote cysteine residue located outside …

Aug 9, 2019 · Analysis of multiple CCA data sets demonstrated that CDK7 was overexpressed in CCA tissues. Further studies demonstrated that CDK7 inhibitor THZ1 inhibited cell viability and …

Using in vitro transcription with nuclear extract, we demonstrate that THZ1, a covalent Cdk7 inhibitor, causes defects in Pol II phosphorylation, co-transcriptional capping, promoter …

Sep 1, 2019 · In this review, we summarized the current understanding with THZ1, a covalent inhibitor of cyclin-dependent kinase 7 (CDK7), which demonstrated promising anti-tumor …

Jan 1, 2021 · In this study, we investigated the role of cyclin-dependent kinase 7 (CDK7) regulation in the treatment of human UCs. Moreover, we studied the effect of THZ1, a CDK7 …

Cdk7 is enriched in SEs, and disruption of SE-dependent transcription appears to be the basis for tumor-selective cytotoxic effects of THZ1 in T-cell leukemia (T-ALL) cells dependent on the …

Jul 20, 2020 · CDK7 silencing and CDK7 inhibitor THZ1 elicited apoptosis and suppressed tumor growth. Moreover, CDK7 ablation specifically suppressed p38α/MYC-associated genes, and …