Our data suggest that the SNP R62W within CD23 that appears to be associated with severity of asthma symptoms in individuals having this genotype may favor increased IgE production …

CD23, also known as Fc epsilon RII, or FcεRII, is the "low-affinity" receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels.

The structure of CD23 and the trimer model, the location of its binding sites for IgE and CD21, and the clustering of CD23 caused by IgE Fc lend support to this mechanism and suggest …

An R62 W SNP of CD23 was demonstrated to cause a functional change in our previous study. TagSNPs were genotyped to comprehensively understand the genomic region and multiple …

Here, we focus on CD23 and discuss several mechanisms related to IgE binding, as well as the impact of the IgE/antigen‐binding on different immune cells expressing CD23. One recent …

Mar 11, 2013 · CD23 is the low-affinity Fc receptor for IgE. When expressed on B cells, CD23 appears to play a role in regulation of IgE synthesis. Polymorphisms within FCER2, the gene …

The data in this report are derived from an analysis of variation in the CD23 gene that leads to a coding exchange and to a single nucleotide polymorphism (SNP) associated with the …

Apr 30, 2013 · CD23, the low affinity receptor for immunoglobulin E (IgE), has been proposed to play a critical role in the regulation of IgE production, based on altered IgE levels in CD23 …

A nonsynonymous single nucleotide polymorphism (SNP) of the low-affinity IgE receptor (FcvarepsilonRII/CD23) gene resulting in an arginine to tryptophan exchange at amino-acid …

May 1, 2012 · One SNP (rs2228137) encodes a nonsynonymous amino acid change (R62W). We established stable human B cell transfectants expressing either wild type CD23b-R62 or …