CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. [5] [6] It helps to detect bacteria in the body by binding …

CD14 was the first identified Pattern Recognition Receptor (PRR) that binds directly to LPS (Wright et al., 1990), and is known to chaperone LPS molecules to the TLR4-MD-2 signaling …

In this review, we focus on the mechanisms of the internalization and intracellular trafficking of TLR4 and CD14, and also of LPS, in immune cells and discuss how dysregulation of the endo …

LPS stimulation of CD14-expressing cells induced TLR4 internalization in the presence of serum, and an inhibitory anti-LBP mAb blocked its internalization. Addition of LBP to serum-free …

Aug 1, 2019 · The extent of CD14 requirement for LPS recognition is affected by concentration and chemotype of LPS. For instances, CD14 is required to activate TLR4 with low LPS …

Dec 30, 2013 · CD14 is 56 kDa protein which forms homodimers and binds lipid portion of LPS in its NH 2 -terminal hydrophobic pocket [12, 13]. The protein is incorporated in the outer leaflet …

Sep 21, 1990 · CD14, a differentiation antigen of monocytes, was found to bind complexes of LPS and LBP, and blockade of CD14 with monoclonal antibodies prevented synthesis of TNF-alpha …

Jun 29, 2018 · LPS stimulation of CD14-expressing cells induced TLR4 internalization in the presence of serum, and an inhibitory anti-LBP mAb blocked its internalization. Addition of LBP …

Lipopolysaccharide binding protein (LBP) is a protein that in humans is encoded by the LBP gene. [5] [6]LBP is a soluble acute-phase protein that binds to bacterial lipopolysaccharide (or LPS) …

Mar 18, 2025 · The LPS-TLR4 immune response is a critical mechanism in the body's defense against Gram-negative bacterial infections, yet its dysregulation can lead to severe …