CD14 (cluster of differentiation 14) is a human protein made mostly by macrophages as part of the innate immune system. [5][6] It helps to detect bacteria in the body by binding …

Mar 30, 2025 · The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate …

The cell surface antigen CD14 is primarily understood to act as a co-receptor for toll-like receptors (TLRs) to activate innate immunity responses to pathogens and tissue injury in macrophages …

Jan 4, 2025 · A polymorphism in the CD14 gene (CD14/-1721) modifies the inverse association of early farm milk consumption on allergic diseases in children in 2 independent rural …

Feb 8, 2025 · The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate …

Aug 1, 2019 · CD14 helps oxPAPC to be transported into cytoplasm to bind with caspase-11 and lead to NLRP3 inflammasome assembly and secretion of IL-1 and IL-18. This CD14-mediated …

Human monocyte differentiation antigen CD14 is a pattern recognition receptor (PRR) that enhances innate immune responses. CD14 was first identified as a marker of monocytes to …

CD14 is a key molecule in the activation of innate immune cells and exists as a membrane-anchored or soluble form. It is encoded by a gene on human chromosome 5q31.1, a region …

Jul 8, 2021 · In the CD14 gene, a promoter polymorphism (rs2569190; c.-260C/T) was shown to be associated with increased transcriptional activity resulting in higher levels of soluble CD14 .

CD14 is a glycosylphosphatidylinositol (GPI)-anchored receptor known to serve as a co-receptor for several Toll-like Receptors (TLRs) both at the cell surface and in the endosomal …