These cRGD-modified liposomes specifically recognized integrin α v β 3 and exhibited greater uptake efficiency with respect to delivering liposomes into HCT116 cells when compared to nontargeted liposomes (Lipo-PEG), as well as greater death of tumor cells and apoptosis.

Mar 8, 2022 · Macrophage membrane- and cRGD-functionalized biomimetic thermosensitive liposomes combined with CPP can escape from clearing of the reticuloendothelial system and realize the precise delivery of siRNA into tumor cells with the help of thermotherapy.

May 11, 2022 · In this study, we investigate the use of low-frequency ultrasound as an external modality to trigger the release of a model drug (calcein) from non-targeted and targeted pegylated liposomes modified with cyclic arginine–glycine–aspartate (cRGD).

The effects of cRGD-CL/pshOC-2 liposome-mediated OC-2 knockdown on colony formation, wound healing and migration of MCF-7 cells were investigated, and their antitumor activity, biodistribution and biosafety were evaluated in mice.

Apr 1, 2019 · Broadly enhanced anticancer potency of cRGD-liposomal 2Cl post UVA activation. Markedly promoted immunogenic cell death through the liposome delivery system. Effectively inhibited tumor growth in vivo through the vaccination application.

Download scientific diagram | Size distribution of the control and cRGD liposomes together with TEM images of the cRGD liposomes. from publication: Ultrasound-sensitive cRGD-modified...

In this study we aimed at developing RGD-targeted thermosentitive liposomes, which combine active targeting of tumors together with a heat-triggered drug release function.

Apr 1, 2014 · Schematic illustration of tumor-specific targeting of liposomes and the release of cargo by thermal triggering. cRGD of the liposome surface binds to α v β 3 integrin, and the liposome may be taken up by cells, presumably via receptor-mediated endocytosis.

There-fore, the purpose of our study was to acquire a new siRNA delivery sys-tem that could release siRNA near the tumor tissues, make siRNA ef ficiently penetrate the cell membrane, and achieve precise siRNA de-livery into the cytoplasm of target cells.

Apr 1, 2019 · We reported here that cRGD target liposome delivery system was capable to promote the immunogenic cell death through enhanced potency of a thymidine conjugate post UVA activation as a cancer vaccine.