Myc proteins are transcription factors that activate expression of many pro-proliferative genes through binding enhancer box sequences (E-boxes) and recruiting histone acetyltransferases (HATs).

Induced c-Myc overexpression coordinates the expression of genes necessary for cells to engage in glutamine catabolism that exceeds the cellular requirement for protein and nucleotide biosynthesis.

The MYC proto-oncogenes encode a family of transcription factors that are among the most commonly activated oncoproteins in human neoplasias. Indeed, MYC aberrations or upregulation of MYC-related pathways by alternate mechanisms occur in the vast ...

Twenty genes were identified, i.e., 17 that are upregulated and 3 that are downregulated by c-Myc. Studies using the Myc-ER fusion protein system are consistent with the idea that one novel gene, rcl, is a direct target of c-Myc.

Mar 30, 2025 · MYC (MYC Proto-Oncogene, BHLH Transcription Factor) is a Protein Coding gene. Diseases associated with MYC include Burkitt Lymphomaand High-Grade B-Cell Lymphoma Double-Hit/Triple-Hit.

Sep 10, 2021 · The MYC proto-oncogenes are among the most commonly activated proteins in human cancer, yet the clinical efficacy of MYC-targeted agents remains to be demonstrated.

c-MYC sensitizes cells to a wide range of pro-apoptotic stimuli in vitro via cytochrome c release from mitochondria and subsequent formation of the apoptosome with APAF1 and procaspase-9.

Jun 29, 2021 · In this Perspective, we highlight how multiple proteins that interact with MYC enable MYC to regulate several central control points of gene transcription. These include promoter binding,...

Mar 27, 2025 · Downregulation of c-Myc is critical for valproic acid-induced growth arrest and myeloid differentiation of acute myeloid leukemia. Cheng YC, et al. Leuk Res, 2007 Oct. PMID 17445886. Deregulating MYC in a model of HER2+ breast cancer mimics human intertumoral heterogeneity. Risom T, et al. J Clin Invest, 2020 Jan 2. PMID 31763993, Free PMC Article.

Know comprehensive c-Myc/MYC protein information including protein sequence, molecular weight, theoretical pI, structure, function and protein interaction.