Jan 29, 1988 · The c-myc gene comprises three exons with a single large AUG-initiated open reading frame extending from exon 2 through exon 3. Exon 1 lacks any AUG codons. Cells from a wide range of species produce two c-myc proteins that, while highly related, do not appear to arise from posttranslational interco …

Truncation of exon 1 from the c-myc gene results in prolonged c-myc mRNa stability. The human c-myc gene consists of three exons transcribed from two distinct promoters and the function of the first, noncoding exon is unknown. In COLO 320 cells, there co-exist normal and truncated (i.e., lacking exon 1) c-myc genes, both of which are transcribed.

Jan 29, 1988 · In this report, we show that the two c-myc proteins also arise from alternate translational initiations in exon 1 and exon 2. The initiation codon for c-Myc-1 in vitro appears to be a CUG.

Oct 8, 2001 · The c-myc gene comprises three exons. Exon 1 contains two promoters and is noncoding. Exons 2 and 3 encode the Myc protein with translation initiation at nucleotide 16 of exon 2.

Dec 30, 1985 · Therefore truncation of the c-myc gene can cause the mRNA to be more stable than the full size product suggesting that this can be a crucial factor in the activation of the c-myc oncogene, by exon 1 loss, in chromosomal translocation.

Thus, removal of the first exon—which occurs in a series of rearrangements of the c-Myc locus—alters the c-Myc promoter structure and halts the expression of isoform p67, which is implicated in growth inhibition.

Activation of the c-myc proto-oncogene by chromosomal translocation or proviral insertion frequently results in the separation of the c-myc coding region from its normal regulatory elements. Such rearrangements are often accompanied by loss …

A Non-AUG Translational Initiation in c-myc Exon 1 Generates an N-Terminally Distinct Protein Whose Synthesis Is Disrupted in Burkitt’s Lymphomas

Published sequence data of the human c-myc gene indicate the presence of a coding capacity for a polypeptide of 188 residues within the first exon.

May 1, 1989 · The presence of myc exon 1 sequences in the cII-mos-myc fusion protein was confirmed by partial amino acid sequence analysis. These experiments further establish that the first exon of the human c-myc gene contains an open reading frame capable of expressing a protein in Escherichia coli.