Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor.

c-Jun, the most extensively studied protein of the activator protein-1 (AP-1) complex, is involved in numerous cell activities, such as proliferation, apoptosis, survival, tumorigenesis and tissue morphogenesis.

The 39-kDa c-Jun protein consists of a C-terminal basic region-leucine zipper (B-ZIP) DNA binding domain and a N-terminal transcriptional activation domain. c-Jun is the prototype of a large group of B-ZIP proteins, which form homo- and heterodimeric complexes capable of binding TPA response element (TRE) DNA recognition motifs (consensus 5 ...

Dec 4, 2019 · Here we show that CAR T cells engineered to overexpress the canonical AP-1 factor c-Jun have enhanced expansion potential, increased functional capacity, diminished terminal differentiation...

We show that in fibroblasts, c-Jun is required for progression through the G1 phase of the cell cycle; c-Jun-mediated G1 progression occurs by a mechanism that involves direct transcriptional control of the cyclin D1 gene, establishing a molecular link between growth factor signaling and cell cycle regulators.

c-Jun is a major component of the dimeric transcription factor activator protein-1 (AP-1), a paradigm for transcriptional response to extracellular signaling, whose components are basic-Leucine Zipper (bZIP) transcription factors of the Jun, Fos, ...

c-Jun, a member of the activation protein 1 (AP-1) family of transcription factors, has been implicated in the regulation of many important biological processes including cell cycle progression, transformation, differentiation, and apoptosis.

Mar 23, 2021 · Here, we identified c-Jun and JunB as essential for cDC1 fate specification and function.

Dec 17, 2011 · In this article, we will provide a brief historical overview of studies on c-Jun regulation and function, and use eyelid development as an example to illustrate the complexity of c-Jun crosstalking with signaling pathways.

Jan 4, 1999 · The results reveal critical roles for c‐Jun in two different cellular processes and show that different extracellular stimuli can target c‐Jun by distinct biochemical mechanisms.