Apolipoprotein AI (Apo-AI) is a protein that in humans is encoded by the APOA1 gene. [5][6] As the major component of high-density lipoprotein (HDL) particles, it has a specific role in lipid metabolism. APOA1 is located on chromosome 11, with its specific location being 11q23-q24. The gene contains 4 exons. [7] .

Apolipoprotein A-I (ApoA-I), the major protein component of high-density lipoproteins (HDL) is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune response regulation.

The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the …

ApoA-I exerts its anti-inflammatory effects mainly by regulating the functions of immune cells, such as monocytes/macrophages, dendritic cells, neutrophils, and T lymphocytes. It also modulates the function of vascular endothelial cells and adipocytes.

Jan 18, 2025 · Apolipoprotein A-I (ApoA-I) is a vital protein that plays a key role in lipid metabolism and cardiovascular health. Moreover, ApoA-I is the primary component of high-density lipoprotein (HDL), commonly referred to as “good cholesterol.”

Apolipoprotein A-I (apo A-I) an indispensable component and a major structural protein of high-density lipoprotein (HDL), plays a vital role in reverse cholesterol transport and cellular cholesterol homeostasis since its identification.

Nov 13, 2017 · Apolipoprotein (apo)A-I is an organizing scaffold protein that is critical to high-density lipoprotein (HDL) structure and metabolism, probably mediating many of its cardioprotective properties....

Feb 8, 2025 · apolipoprotein A-I, apo-AI, epididymis secretory sperm binding protein. Oxidant resistant human apolipoprotein A-I functions similarly to the unmodified human isoform in delaying atherosclerosis progression and promoting atherosclerosis regression in hyperlipidemic mice.

Jun 29, 2023 · ApoA-I—the main apolipoprotein constituent of the HDL (high-density lipoprotein) fraction of human plasma—is of therapeutic interest because it has several cardioprotective functions. Recent reports have established that apoA-I also has antidiabetic properties.

Mar 28, 2025 · This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma.