Anti-HER2 therapies (also called HER2 inhibitors or HER2-targeted therapies) are a class of medicines used to treat all stages of HER2-positive breast cancer and certain HER2-low breast cancers.

Nov 7, 2022 · This Review discusses the current standards of care for HER2-positive breast cancer, mechanisms of resistance to HER2-targeted therapy and new therapeutic approaches and agents, including...

Oct 22, 2024 · There are three typical treatment strategies: Most common: neoadjuvant chemotherapy plus HER2-targeted therapy. Most people with HER2+ breast cancer, including those with very small...

Jul 24, 2024 · The first HER2-targeted therapy, trastuzumab (Herceptin) combined with chemotherapy, improved overall survival outcomes of these cancers by 30% and reduced the risk of recurrence by 50%, says Mayo Clinic oncologist Ciara O’Sullivan, M.B., B.Ch.

Current research in anti-HER2 therapy is focusing on developing novel TKIs, ADCs, bispecific antibodies, CAR-T, immunotherapy, and inhibiting protein production or increasing degradation.

Anti-HER2 agents dramatically changed the natural course of disease and significantly prolonged patients’ survival. In recent years, a number of new anti-HER2 therapies have been developed, and their approvals offer new therapeutic options for …

Feb 2, 2024 · Trastuzumab, a monoclonal antibody, represents the most advanced drug targeting anti-HER2 therapy and has gained approval the treatment of breast cancer (BC), GC and mCRC treatment [172].

In the third-line setting and beyond, several emerging anti-HER2 therapies are becoming available, including tucatinib, fam-trastuzumab deruxtecan-nxki (DS-8201a), neratinib, and margetuximab-cmkb. In addition, new compounds and combinations are showing promising results in the late-line setting.

HER2 inhibitors are used in the treatment of breast cancer. For ratings, users were asked how effective they found the medicine while considering positive/adverse effects and ease of use (1 = not effective, 10 = most effective). Medical conditions treated or associated with HER2 inhibitors:

Aug 10, 2021 · Targeted drug therapy uses medicines that are directed at (target) proteins on breast cancer cells that help them grow, spread, and live longer. Targeted drugs work to destroy cancer cells or slow down their growth. They have side effects different from chemotherapy.