CD28 serves as a receptor for CD80 (B7.1) and CD86 (B7.2), proteins found on antigen-presenting cells (APCs). CD28 is the only B7 receptor consistently expressed on naive T cells. …

T cell activation via the αβ-T cell receptor (TCR complex) is required for in vitro expansion. Treatment of T cells with monoclonal anti-CD3 antibodies and anti-CD28 antibodies provide a …

Antibodies that detect CD28 can be used in several scientific applications, including Flow Cytometry, Western Blot, ELISA, Immunohistochemistry and Functional Assay. These …

Here, we describe the generation, characterization, and in vivo safety validation of a new anti-human CD28 mAb termed “E1P2.” E1P2 is a fully human mAb isolated by phage display …

CD28 binds both CD80 and CD86 using a highly conserved motif MYPPY in the CDR3-like loop. CD28 is considered a major co-stimulatory molecule, inducing T lymphocyte activation and IL …

CD28 is critical for regulatory T cell survival and the maintenance of immune homeostasis. We outline the roles that CD28 and its family members play in human disease and we review the …

Sep 7, 2006 · Six healthy young male volunteers at a contract research organization were enrolled in the first phase 1 clinical trial of TGN1412, a novel superagonist anti-CD28 …

0.2 µm filtered in phosphate-buffered solution, pH 7.2, containing no preservative. Less than 0.01 EU/µg of the protein (< 0.001 ng/µg of the protein) as determined by the LAL test. The Ultra …

The CD28 antibody recognizes the human CD28 antigen, a type I transmembrane protein, which is highly expressed on CD3+ thymocytes, most peripheral thymocytes and plasma cells.

After having demonstrated outstanding therapeutic efficacy in multiple models of autoimmunity, inflammation and transplantation, and safety in phase-I studies in humans, selective CD28 …