The Z-factor is a measure of statistical effect size. It has been proposed for use in high-throughput screening (HTS), where it is also known as Z-prime, [ 1 ] to judge whether the response in a particular assay is large enough to warrant further attention.

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A Z-factor between 0.5 and 1.0 is an excellent assay. A Z-factor between 0 and 0.5 is marginal. A Z-factor less than 0 means that the signal from the positive and negative controls could overlap, making the assay not very useful or screening purposes.

Z factor (Z′ factor) is a statistical data quality indicator for a bioassay, particularly that used in the field of high throughput screening (HTS). In most HTS programs in drug discovery, each compound from a chemical library is only evaluated in a single test during primary screening.

Jan 27, 2025 · Z prime value or Z prime factor, which is also referred to as Z’, is one crucial parameter for measurements in the life sciences particularly for data acquisition in high throughput screening in drug discovery.

The Z Factor, also known as the Z-score, is a statistical measurement that describes a value’s relationship to the mean of a group of values. It indicates how many standard deviations an element is from the mean.

The Z factor is a widely used method that determine whether the compounds or the value-added reagents are worth investigating forward during the initial screening process. This paper will address how Z-factor and Z’-factor are calculated, and the limitation of the Z- and Z’-factor.

Jul 27, 2023 · Enter the mean and standard deviations of the positive and negative controls to determine the Z-factor.

Mar 30, 2023 · Matthew Lloyd from the University of Bath reveals the importance of the Z-factor and Z’-factor in high-throughput screening, and how they can be used to determine assay performance, perform quality control on the screen, and identify active compounds.

Z-factor (Z0-factor) is a statistical data quality indicator for a bioassay, particularly, that used in the field of high-throughput screening (HTS). In most HTS programs in drug discovery, each compound from a chemical library is only evalu-ated in a single test during primary screening. A high degree of accuracy and sensitivity in the