The DNA-binding sites of YY1 located within two newly identified downstream genes of YY1, Peg3 (GGCGCCATnTT) and Xist (CCGCCATnTT), are longer than the known motif of YY1 (CGCCATnTT).

Mar 30, 2025 · YY1 (YY1 Transcription Factor) is a Protein Coding gene. Diseases associated with YY1 include Gabriele-De Vries Syndrome and Insulinoma. Among its related pathways are Gene expression (Transcription) and ESR-mediated signaling.

Nov 16, 2020 · Recently, YY1 was found to promote the formation of enhancer–promoter loops, which involves interaction of YY1 with duplex DNA harboring a consensus YY1-binding motif 15. Here, by using an...

Nov 28, 2005 · YY1 is a ubiquitous and multifunctional zinc-finger transcription factor (also known as δ, NF-E1, UCRBP, and CF1) member of the Polycomb Group protein family, a group of homeobox gene...

May 3, 2007 · DNA-binding motif studies have demonstrated that YY2 still binds to the same consensus sequence as YY1 but with much lower affinity. In contrast, REX1 binds to DNA motifs divergent from YY1, but the binding motifs of REX1 and YY1 share some similarity at their core regions (5′-CCAT-3′).

YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

Dec 14, 2017 · YY1 binds to active enhancers and promoter-proximal elements and forms dimers that facilitate the interaction of these DNA elements. Deletion of YY1 binding sites or depletion of YY1 protein disrupts enhancer-promoter looping and gene expression.

Oct 26, 2024 · Putative YY1-binding motifs have been predicted in the 5′UTRs of two distinct mouse L1 subfamilies, Tf and Gf. Using site-directed mutagenesis, in vitro binding and gene knockdown assays, we experimentally tested the role of YY1 in mouse L1 transcription.

Feb 1, 2009 · The DNA-binding sites of YY1 located within two newly identified downstream genes of YY1, Peg3 (GG CGCCATnTT) and Xist (C CGCCATnTT), are longer than the known motif of YY1 (CGCCATnTT). Gel shift assays indicated that these DNA-binding sites are previously unnoticed, longer motifs of YY1.

Sep 30, 2020 · YY1 homodimers bind a relatively small sequence motif (5′-CCGCCATNTT-3′), often found in enhancers and promoters, via the four C2H2 zinc fingers in its C-terminal domain (Hyde-DeRuyscher et al., 1995; Yant et al., 1995; Figure 1).