YY1 is a multifunctional transcription factor that acts as an activator or repressor in different contexts. YY1 binds to multiple sites in the mouse c-fos promoter, inducing at each site a sharp DNA bend. Binding of YY1 to a site situated between ...

We present evidence that YY1, a ubiquitously expressed DNA-binding protein, regulates the activity of the c-fos promoter primarily through an effect on DNA structure. YY1 binds to and induces a phased DNA bend at three sites in this promoter.

YY1 is a multifunctional transcription factor that acts as an activator or repressor in different contexts. YY1 binds to multiple sites in the mouse c-fos promoter, inducing at each site a sharp DNA bend.

Overexpression of YY1 in HeLa cells resulted in repression of a mutant c-fos chloramphenicol acetyltransferase reporter that lacked binding sites for YY1, suggesting that repression can be triggered through protein-protein interactions with ATF/CREB family members.

YY1 binds to multiple sites in the mouse c-fos promoter. (A) Mobility retardation assays of bacterially expressed YY1 on probes corresponding to three regions in the mouse c-fos promoter.

YY1 and CTCF share many features: both are essential, ubiquitously expressed, zinc-coordinating proteins that bind hypo-methylated DNA sequences, form homodimers, and thus facilitate loop formation.

Mar 16, 2015 · In this study we found that YY1 was upregulated by IL-13 in lung fibroblasts in a dose- and time-dependent manner, resulting in increased α-SMA. Conversely, knockdown of YY1 blocked IL-13-induced α-SMA expression in fibroblasts.

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YY1 is a multifunctional transcription factor that acts as an activator or repressor in different contexts. YY1 binds to multiple sites in the mouse c-fos promoter, inducing at each site a sharp DNA bend.

YY1 binds to DNA through the recognition of a specific consensus sequence, leading to the activation or repression of many cellular genes including c-Myc, c-Fos, β-actin, IFN-γ, CREB, Sp1, and others (3, 4).