Aug 7, 2024 · Ythdf1 deletion resembled impairment caused by Mettl14 deletion in a cell type-specific manner, suggesting YTHDF1 is the main mediator of the functional consequences of m 6 A mRNA methylation in the striatum.

YTHDF1 is the most versatile and powerful reader protein of N6 -methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.

Jan 28, 2023 · As the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation in cytoplasm. It is highly expressed in various human cancers and contributes to the progression...

Integrated MeRIP-seq, RNA-seq and Ribo-seq revealed p65/Rela as a YTHDF1 target. YTHDF1 promoted p65 translation to upregulate CXCL1, which increased MDSC migration via CXCL1-CXCR2 axis. Increased MSDCs in turn antagonised functional CD8 + T cells in TIME.

YTHDF1 is a versatile reader for m6A modifications, and its main function is to mediate protein translation of downstream genes. According to a recent study on colon cancer, YTHDF1 can promote the translation of RELA, participate in the NF‐κB pathway, and promote tumor development [30].

Feb 6, 2019 · Here we show that durable neoantigen-specific immunity is regulated by mRNA N6 -methyadenosine (m 6 A) methylation through the m 6 A-binding protein YTHDF1 5. In contrast to wild-type mice,...

5 days ago · Importantly, SF3B2 overexpression rescued the suppressed proliferation and invasion caused by YTHDF1 knockdown in SW1990 and PANC-1 cells. Collectively, our findings demonstrate that YTHDF1 drives pancreatic cancer progression by enhancing SF3B2 translation through m 6 A modification, thereby providing novel mechanistic insights and a potential ...

Jan 13, 2025 · YTHDF1 was found to enhance GBP4 expression by recognizing m6A sites on its mRNA, which was linked to reduced inflammation in MLE-12 cells upon YTHDF1 knockdown. The study emphasizes the crucial roles of GBP4 and YTHDF1 in ALI development and immune response regulation.

As the m6A reader protein, YTHDF1 is reported to accelerate m6A-modified mRNAs translation in cytoplasm. It is highly expressed in various human cancers and contributes to the progression and metastasis of cancers.

Dec 3, 2021 · YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.