Feb 16, 2022 · After feeding for 6 hours, B. lactis BL-99 was fully retained in the larval zebrafish intestinal tract and stayed for over 24 hours. B. lactis BL-99 promoted the intestinal motility and effectively alleviated aluminum sulfate-induced larval zebrafish constipation (p < 0.01).

Jan 3, 2024 · Further metagenomic and metabolomics revealed that BL-99 promoted the accumulation of SCFA-producing microbiota and the increase of SCFA levels in stool and serum, which may account for the...

Jan 3, 2024 · Probiotics have the sustainable potential to alleviate FD. This randomized controlled clinical trial (Chinese Clinical Trial Registry, ChiCTR2000041430) assigned 200 FD patients to receive placebo, positive-drug (rabeprazole), or Bifidobacterium animalis subsp. lactis BL-99 (BL-99; low, high doses) for 8-week.

Jan 23, 2023 · The results showed that BL-99 decreased weight loss, disease activity index score, colonic pathology score, and the production of pro-inflammatory cytokines (e.g., TNF-α, IL-1β, and IL-6) in colitis mice.

Jan 11, 2024 · 动物双歧杆菌乳亚种BL-99，可帮助改善胃肠道菌群平衡，提高胃肠道消化能力、改善骨骼健康、调节免疫力；副干酪乳酪杆菌K56，有助于促进脂肪细胞代谢、加速脂肪细胞分解，进而达到减缓肥胖的作用；副干酪乳酪杆菌ET-22，有助于预防龋齿、抑制口腔致病菌和清新口气，有效改善国民口腔健康。 此次伊利集团在《Nature...

Bifidobacterium animalis subsp. lactis BL-99 (BL-99) can alleviate osteoporosis caused by UC, but less research has been done on other extraintestinal manifestations (EIM) caused by UC. This study aimed to explore the role and potential mechanisms of BL-99 on DSS-induced pulmonary complications in colitis mice.

Jan 18, 2022 · To that end, the ability of Bifidobacterium lactis BL-99 administration to protect against bone loss in an experimental model of dextran sodium sulfate-induced ulcerative colitis (UC) was analyzed, and the underlying molecular mechanisms were interrogated in detail.

After feed-ing for 6 hours, B. lactis BL-99 was fully retained in the larval zebrafish intestinal tract and stayed for over 24 hours. B. lactis BL-99 promoted the intestinal motility and effectively alle-viated aluminum sulfate-induced larval zebrafish constipation (p < 0.01).

Jul 29, 2021 · Our findings demonstrated that B. lactis BL-99 and L. paracasei K56 and ET-22 can achieve the generally recognized as safe (GRAS) status as probiotics in the future. Keywords: Bifidobacterium lactis; Lacticaseibacillus paracasei; probiotics; safety assessment; toxicity.

Our study aimed to identify the effect of BL99-derived-MV (BL99-MV) on LPS-induced HT22 inflammatory injury. To this end, we might clarify the protective effect of BL99-MV on HT22 under LPS-induced HNF to provide a theoretical foundation for early intervention strategies.