Sep 5, 2023 · Immunohistochemical stain shows positive nuclear staining of the N terminus of YAP1 but loss of staining of the C terminus. Fluorescence in situ hybridization using YAP1 break apart probe confirms rearrangement of YAP1 gene.

Yes-associated protein (YAP) is a downstream regulatory target in the Hippo signaling pathway that is upregulated in SHH (sonic hedgehog)-associated medulloblastomas and medulloblastomas with activation of the Wnt (wingless-related integration site) signaling pathway and is expressed in lung, placenta, prostate, ovary, and testis.

Yes-associated protein (YAP), the core downstream transcription co-activator of the Hippo signaling pathway, is the key mediator of mechanotransduction signaling that works in a complex with another transcriptional co-activator with PDZ-binding motif (TAZ) following tissue injury [23, …

YAP (Yes-associated protein) is a transcriptional coactivator that mediates mechanical and biochemical signals controlling fibroblast activation. In this study, we developed a high-throughput small-molecule screen for YAP inhibitors in primary human lung fibroblasts.

Yes-associated protein (YAP) is a downstream regulatory target in the Hippo signaling pathway that is upregulated in SHH (sonic hedgehog)-associated medulloblastomas and medulloblastomas with activation of the Wnt (wingless-related integration site) signaling pathway and is expressed in lung, placenta, prostate, ovary, and testis.

Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) are related mechanosensory proteins that bind to Smad transcription factors, the canonical mediators of profibrotic TGF- β responses. Here, we investigated the role of YAP/TAZ in the matrix stiffness dependence of fibroblast responses to TGF- β.

In the following report, IHC procedures optimized for the detection of YAP in tissue slides of FFPE material are provided. Of note, de-paraffinization and heat-induced antigen retrieval are strictly necessary for successful YAP IHC staining.

We have studied the immunohistochemical expression of YAP in different RMSs, arranged in tissue microarray (TMA) and whole slide formats. Pertinent clinical data including patient age, gender, tumor location, and clinical stage were collected.

Aug 28, 2018 · Podocytes display a predominant nuclear localization of YAP (Yes-associated protein), one effector protein of the Hippo pathway, which regulates the balance between proliferation,...

A comparison of the staining patterns of total Yap and phosphorylated Yap (pYap) revealed a pattern that mirrored Yap cytoplasmic signals and suggested that cytoplasmic Yap is in its phosphorylated form, as reported in other contexts (Figure 1C).