Specifically, yes-associated protein 1 (YAP)-mediated mechanosignaling regulated the induction of osteopontin (OPN), a mechanoresponsive marker for PDL maintenance, and periostin, a PDL-specific marker in periodontal tissue remodeling.

Dec 15, 2020 · In hepatocytes and tumor cells, YAP/TEA domain transcription factor 4 (TEAD4)–dependent transcriptional induction of osteopontin (Opn) stimulated c-Met expression in EC with CEC phenotype, which sensitized these cells …

Oct 14, 2022 · In vitro, recombinant OPN stimulated cardiac cell outgrowth, cardiomyocyte (CM) cell-cycle re-entry, and CM migration. In addition, OPN induced nuclear translocation of the cytoplasmatic yes-associated protein 1 (YAP1) and upregulated transcriptional factors …

Aug 19, 2022 · In hepatocytes, YAP/TEAD4 induces OPN transcription, which stimulates c-Met expression in endothelial cells and then contributes to the formation of a tumor-supporting vascular microenvironment [53].

Mar 22, 2024 · In ~10% of human cancers, Hippo pathway dysregulation results in YAP/TAZ overactivation and increased TEAD-dependent transcription that promotes tumor growth and therapy resistance - often by supporting drug-tolerant persister survival.

This study was aimed to evaluate the possible links between ECM component alteration after cancer surgery and OPN and Yes-associated protein (YAP) expression in TCC and adjacent tissues.

Jun 4, 2021 · We conducted YAP and IHH gene expression on human bladder TCCs and healthy adjacent tissue samples to investigate the possible correlation between YAP and IHH as well as OPN expression.

This study was aimed to evaluate the possible links between ECM component alteration after cancer surgery and OPN and Yes-associated protein (YAP) expression in TCC and adjacent tissues.

Here, we identify a self-amplifying, self-propagating loop of Yes-associated protein (YAP)–Sonic hedgehog (SHH) as a core molecular mechanism underlying diverse forms of HO.

Dec 10, 2022 · The expression of autophagy-related markers and YAP were up-regulated in VSMCs during phenotypic transitioning, and YAP may promote autophagy by upreglute the expression of Beclin1 and ultimately accelerate phenotypic transition.