YAP antagonizes innate antiviral immunity and is targeted for
May 8, 2017 · In the present study, we identified YAP as a negative regulator of innate immunity to RNA and DNA viruses. YAP interacted with IRF3 and impaired the formation of IRF3 dimers …
Targeting IRF3 as a YAP agonist therapy against gastric cancer
Feb 5, 2018 · In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric …
Targeting IRF3 as a YAP agonist therapy against gastric cancer
In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric cancer; the …
The Crosstalk Between Hippo-YAP Pathway and Innate Immunity
We found YAP interacted with IRF3, a critical transcription factor in innate immunity, and prevented its dimerization and nuclear translocation, which further reduced the production of …
microRNA-365 inhibits YAP through TLR4-mediated IRF3 …
Nov 13, 2024 · IRF3 is a well-defined signal transduction factor/transcription factor that is essential for the innate antiviral response. IRF3 promotes the nuclear translocation and …
In this study, we discovered IrF3 as an agonist of Yes-associated protein (YAP). the expression of IrF3 is positively correlated with that of YAP and its target genes in gastric cancer;...
Hippo interferes with antiviral defences - Nature Cell Biology
Mar 31, 2017 · Activation of the Hippo pathway by starvation or cell–cell contact induces YAP/TAZ phosphorylation and its subsequent degradation allows TBK1 association with IKKɛ, to …
microRNA-365 inhibits YAP through TLR4-mediated IRF3 …
Nov 13, 2020 · IRF3 is a well-defined signal transduction factor/transcription factor that is essential for the innate antiviral response. IRF3 promotes the nuclear translocation and …
YAP antagonizes innate antiviral immunity and is targeted for …
YAP deficiency resulted in enhanced innate immunity, a diminished viral load, and morbidity in vivo. YAP blocked dimerization of the transcription factor IRF3 and impeded translocation of …
Targeting IRF3 as a YAP agonist therapy against gastric cancer
Jan 16, 2018 · In this study, we discovered IRF3 as an agonist of Yes-associated protein (YAP). The expression of IRF3 is positively correlated with that of YAP and its target genes in gastric …