Xist (X-inactive specific transcript) is a non-coding RNA transcribed from the X chromosome of the placental mammals that acts as a major effector of the X-inactivation process. [5] It is a …

Mar 30, 2025 · XIST (X Inactive Specific Transcript) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with XIST include X Inactivation, Familial Skewed, 1 and …

Xist RNA is the master regulator of X-chromosome inactivation (XCI), the epigenetic process that equalizes the dosage of X-linked genes between female (XX) and male (XY) mammals.

In this manuscript, we summarize the current knowledge about the mechanisms for XIST -mediated XCI and the roles of XIST in sex-biased diseases, and discuss potential therapeutic …

Xist is among the first regulatory RNAs discovered and implicated in formation of the inactive X chromosome (Xi). This review focuses on the analysis of Xist function and its molecular …

Aug 15, 2015 · We discuss recent advances in our knowledge of Xist-mediated silencing, focusing on Xist spreading, the nuclear organization of the inactive X chromosome, recruitment of the …

Feb 1, 2024 · Scientists say a molecule known as Xist that is associated with X chromosomes may explain why women are at far greater risk of developing an autoimmune disease than men

Jan 4, 2024 · We found that XIST spreads across the X chromosome and induces dampening of X-linked gene expression in naive hPSCs. Surprisingly, XIST also targets specific autosomal …

Jun 15, 2021 · Cell differentiation, Xist upregulation and gene silencing are thought to be coupled at multiple levels to ensure inactivation of exactly one out of two X chromosomes. Here we …

Jun 4, 2024 · We show that XIST triggers the deposition of polycomb-mediated repressive histone modifications and dampens the transcription of most X-linked genes in a SPEN-dependent …