Days 1–5 OR 1–7: 5-FU 225mg/m2 IV over 24 hrs during XRT. Days 1–4: Leucovorin 20mg/m2 IV bolus, followed by 5-FU 400g/m2 IV bolus during XRT. Repeat during weeks 1 and 5 of XRT. Days 1–5 OR 1–7: Capecitabine 825mg/m2 twice daily + XRT. Repeat weekly for 5 weeks. 2 days (total 2,400mg/m2) as a 46–48 hr continuous infusion. Repeat every 2 weeks.

Aug 1, 2006 · Patients and methods: After resection of T3-4, N0, M0 or T1-4, N1, 2M0 rectal adenocarcinoma, 1,917 patients were randomly assigned to arm 1, with bolus FU in two 5-day cycles every 28 days before and after radiotherapy (XRT) plus FU via protracted venous infusion (PVI) 225 mg/m2/d during XRT; arm 2 (PVI-only arm), with PVI 42 days before and ...

Mar 1, 1994 · Intergroup 0144 - phase III trial of 5-FU based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer. Bolus 5-FU vs prolonged venous infusion (PVI) before and after XRT + PVI vs bolus 5-FU + leucovorin (LV) + levamisole (LEV) before and after XRT + bolus 5-FU + LV.

Nov 15, 2007 · Smalley SR, Benedetti J, Williamson S, et al. Intergroup 0144—phase III trial of 5-FU based chemotherapy regimens plus radiotherapy (XRT) in postoperative adjuvant rectal cancer. Bolus 5-FU vs prolonged venous infusion (PVI) before and after XRT + PVI vs bolus 5-FU + leucovorin + levamisole before and after XRT + bolus 5-FU + LV [abstract].

Aug 1, 2006 · Adjuvant chemoradiotherapy after or before resection of high-risk rectal cancer improves overall survival (OS) and pelvic control. We studied three postoperative fluorouracil (FU) radiochemotherapy regimens.

RT alone improves local control, but not survival. RT plus continued infusion of 5-FU improves survival over bolus 5-FU. Other concurrent drugs have so far not shown additional benefit over C.I. 5-FU. At this time, RT alone is considered inadequate. …

Intergroup 0144 a phase III rectal surgical adjuvant study of pelvic radiation (XRT) plus 5-FU based chemotherapy (bolus 5-FU before and after PVI + XRT vs PVI before, during, and after XRT vs biochemically modulated bolus 5-FU and XRT): …

Apr 27, 2023 · Bolus FU was administered before, during, and after pelvic radiotherapy (XRT) versus the same pre- and post-XRT bolus schedule, but with PVI administered with XRT.

Oct 1, 1991 · In the present study, the addition of MMC and 5FU to XRT, both administered by iv bolus injection, and in the dose schedules used, added significantly to the acute treatment morbidity and had no apparent benefit in terms of survival or …

Days 1–4: Leucovorin 20mg/m2 IV bolus, followed by 5-FU 400g/m2 IV bolus during XRT. Repeat cycle during weeks 1 and 5 of XRT. Days 1–5 OR 1–7: Capecitabine 825mg/m2 twice daily + XRT. Repeat cycle weekly for 5 weeks. 2 days (total 2,400mg/m2) as a 46–48-hour continuous infusion. Repeat cycle every 2 weeks.