5 days ago · Polyclonal Antibody for studying XIAP. Validated for WB, WB. Available in 3 sizes. Highly specific and rigorously validated in-house, XIAP Antibody (CST #2042) is ready to ship.

The transcript size of Xiap is 9.0kb, with an open reading frame of 1.8kb. [4] Xiap mRNA has been observed in all human adult and fetal tissues "except peripheral blood leukocytes". [4] The XIAP sequences led to the discovery of other members of the IAP family.

Mar 30, 2025 · XIAP (X-Linked Inhibitor Of Apoptosis) is a Protein Coding gene. Diseases associated with XIAP include Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome 2. Among its related pathways are SMAC (DIABLO) binds to IAPs and TNF signaling.

XIAP has a molecular mass of approximately 57 kDa. This protein inhibits apoptosis by binding to and inhibiting caspases particularly caspase-3 caspase-7 and caspase-9. XIAP expresses in a variety of tissues including the heart kidney and liver but also shows expression in cancer cells.

10037-1-Ig targets XIAP in WB, IHC, CoIP, ELISA applications and shows reactivity with human, rat, mouse samples. PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA.

Sep 16, 2020 · The transcript size of the Xiap gene is about 9.0 kb and contains a 1.8 kb open reading frame . In addition to three IAPs characteristic BIR (baculoviral IAP repeat) motifs at the N-terminal region, full-length XIAP contains an UBA (ubiquitin-associated) domain followed by a RING finger domain.

Read at excitation and emission wavelengths of 400 nm and 505 nm, respectively in kinetic mode for 5 minutes. Derive the 50% inhibiting concentration (IC 50) of rhXIAP by plotting RFU/min (or specific activity) vs. concentration with 4-PL fitting.

X-linked inhibitor of apoptosis protein (XIAP) finely tunes the balance between survival and death to control homeostasis. XIAP is found aberrantly expressed in cancer, which has been shown to promote resistance to therapy-induced apoptosis and ...

Sep 9, 2019 · Here, the first structural model of the full-length XIAP dimer, determined by an integrated approach using nuclear magnetic resonance, small-angle X-ray scattering and electron paramagnetic resonance data, is presented.

Dec 2, 2005 · Small molecule XIAP inhibitors that target the baculovirus IAP repeat (BIR) 2 or BIR 3 domain are in preclinical development and are advancing toward the clinic. This review will discuss the...