4 days ago · XIAP Antibody detects endogenous levels of total XIAP protein. The antibody does not cross-react with other inhibitors of apoptosis. Human, Mouse, Rat, Monkey. Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the amino terminus of human XIAP.

4 days ago · Monoclonal Antibody for studying XIAP. Validated for WB. Available in 2 sizes. Highly specific and rigorously validated in-house, XIAP (3B6) Rabbit Monoclonal Antibody (CST #2045) is ready to ship.

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome. [4] [5]

XIAP (X-chromosome linked inhibitor of apoptosis) is a member of the inhibitor of apoptosis (IAP) family of proteins that inhibit caspases. The BIR2 domain of XIAP inhibits Caspase-3 and Caspase-7. The BIR3 domain inhibits Caspase-9.

Sep 3, 2021 · Briefly, the gene encoding full-length wild type XIAP (a.a. 1–497) was cloned in the pDEST-His-MBP vector, which adds a GSF sequence at the N-terminus of the protein after cleavage of the tag (computed MW: 56,845 Da).

XIAP is an inhibitor of caspase-3, -7 and -9. It mediates activation of MAP3K7/TAK1, leading to the activation of NF-kappa-B. XIAP is an apoptotic suppressor. It is ubiquitinated and degraded by the proteasome in apoptotic cells. The MW of XIAP is 45-56kd.

XIAP Monoclonal Antibody (clone 3B6), Rabbit Store at –20°C Catalog Number: A16522 Pub. No. MAN0009154 Rev. 1.00 Clonality: Monoclonal Amount: 100 μL Host/Class: Rabbit IgG. Reactivity: Human XIAP . Species Reactivity: Human, Monkey . Product Description . XIAP is a memeber of the inhibitor of apoptosis protein (IAP)

Jan 24, 2001 · RING-type E3 ubiquitin transferase XIAP; X-linked inhibitor of apoptosis protein (X-linked IAP)

Sep 9, 2019 · Here, the first structural model of the full-length XIAP dimer, determined by an integrated approach using nuclear magnetic resonance, small-angle X-ray scattering and electron paramagnetic resonance data, is presented.

Jan 28, 2016 · Herein, we demonstrate that the most potent caspase inhibitor, X-linked inhibitor of apoptosis protein (XIAP), overexpressed in IBC, drives resistance to ADCC mediated by cetuximab (anti-EGFR)...