Mar 30, 2025 · XIAP (X-Linked Inhibitor Of Apoptosis) is a Protein Coding gene. Diseases associated with XIAP include Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome 2. Among its related pathways are SMAC (DIABLO) binds to IAPs and TNF signaling.

X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome. [4] [5]

XLP2 is caused by a change in the XIAP gene. This is sometimes called the BIRC4 gene. The XIAP gene codes for the XIAP protein that the body needs to regulate the immune system.

X-linked inhibitor of apoptosis (XIAP) deficiency is a rare inborn error of immunity caused by mutations in the XIAP/BIRC4 gene. The disease is estimated to occur in 1–2 per million live male births .

The XIAP gene produces a protein known as X-linked inhibitor of apoptosis (XIAP), which functions to prevent cell death. When alterations in the XIAP gene are present, usually less XIAP protein is produced, which is believed to result in decreased numbers …

The XIAP gene provides instructions for making a protein that is found in many types of cells, including immune cells. It helps protect these cells from self-destructing (undergoing apoptosis) by blocking (inhibiting) the action of certain enzymes called …

Mar 27, 2025 · XIAP exerts its anti-apoptotic effects by inhibiting both the death receptor pathway and mitochondrial pathway of apoptosis through various mechanisms such as directly binding to caspases, activating the nuclear factor kappa B (NF-κB) pathway, and other signaling pathways.

Feb 9, 2025 · This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function.

Feb 19, 2025 · XIAP is an ovarian cancer-related gene and potential target for therapeutic anti-cancer drugs. Membrane-associated XIAP induces mitochondrial outer membrane permeabilization leading to cytochrome c and Smac release, which is dependent on Bax and Bak.

The XIAP gene belongs to the 'inhibitor of apoptosis protein' (IAP) gene family, which also includes HIAP1 (601721), and HIAP2 (601712). XIAP has a capacity to block apoptosis by directly inhibiting certain caspases.