XIAP (X-linked IAP) is the only family member that suppresses apoptosis by directly binding to and inhibiting caspases. On the other hand, cIAPs suppress the activation of the extrinsic …

Jan 7, 2011 · ARTS, a mitochondrial-localized protein, was shown to promote apoptosis by binding XIAP (Gottfried et al., 2004). Apoptotic stimuli cause the release of ARTS from …

Jun 25, 2020 · The pro-apoptotic ARTS (Sept4_i2) protein binds directly to both Bcl-2 and XIAP and promotes apoptosis by stimulating their degradation via the ubiquitin-proteasome system …

Aug 1, 2022 · Recent research has shown that ARTS can bind and inhibit XIAP and Bcl-2 directly or assist p53 in the degradation of Bcl-XL. Here, we review recent advances in the molecular …

Mar 9, 2020 · ARTS can promote apoptosis by binding and degrading XIAP via the ubiquitin proteasome-system (UPS). Smac can induce the degradation of cIAPs but not XIAP. Many …

Oct 10, 2017 · We show that the pro-apoptotic XIAP-antagonist ARTS is required for down-regulation of Bcl-2 levels upon induction of apoptosis. ARTS directly binds to the BH3 domain …

Using in vivo (live-cell) and in vitro (cell-free reconstituted system) ubiquitylation assays, we show that the XIAP-antagonist ARTS regulates the levels of p53 by promoting the degradation of …

Apr 30, 2012 · Here, we investigated the ability of peptides derived from ARTS to antagonize XIAP and promote apoptosis in cancer cell lines. Experimental Design: The ability of synthetic …

ARTS (Apoptosis-Related protein in the TGF-β Signaling pathway) is a mitochondrial protein that binds XIAP (X-linked Inhibitor of Apoptosis Protein) upon entering the cytosol, thus promoting …

Aug 26, 2011 · ARTS (Sept4_i2) is a pro-apoptotic tumor suppressor protein that functions as an antagonist of X-linked IAP (XIAP) to promote apoptosis. It is generally thought that …