X-linked inhibitor of apoptosis protein (XIAP), also known as inhibitor of apoptosis protein 3 (IAP3) and baculoviral IAP repeat-containing protein 4 (BIRC4), is a protein that stops apoptotic cell death. In humans, this protein (XIAP) is produced by a gene named XIAP gene located on the X chromosome. [4] [5]

X-linked inhibitor of apoptosis (XIAP) deficiency is a rare inborn error of immunity first described in 2006. XIAP deficiency is characterised by immune dysregulation and a broad spectrum of clinical manifestations, including haemophagocytic ...

XIAP deficiency can be considered as one of the genetic causes for inherited IBD. XIAP is an anti-apoptotic molecule, but it is also involved in many other pathways. Recent findings demonstrate the role of XIAP in innate immunity and in the negative regulation of inflammation.

Mar 30, 2025 · XIAP (X-Linked Inhibitor Of Apoptosis) is a Protein Coding gene. Diseases associated with XIAP include Lymphoproliferative Syndrome, X-Linked, 2 and Lymphoproliferative Syndrome 2. Among its related pathways are SMAC (DIABLO) binds to IAPs and TNF signaling.

Jul 10, 2009 · The ability of the vertebrate X-linked inhibitor of apoptosis (XIAP) protein to directly suppress apoptotic cell death pathways has been the subject of much research.

What is XLP2 or XIAP Deficiency? XLP2 is a type of X-linked lymphoproliferative disease. XLP2 typically affects males. It can also occasionally affect females. The condition was first described in 2006. Only about 100 young males have been diagnosed with it so far. XIAP Deficiency Causes. XLP2 is caused by a change in the XIAP gene.

May 8, 2006 · The most intensively studied family member, X-linked IAP (XIAP), is a potent inhibitor of caspase activity; hence, it is generally assumed that direct caspase inhibition is an important conserved function of most members of the family.

The XIAP gene provides instructions for making a protein that is found in many types of cells, including immune cells. It helps protect these cells from self-destructing (undergoing apoptosis) by blocking (inhibiting) the action of certain enzymes called …

Jun 4, 2022 · In addition of anti-apoptotic activities of XIAP as a direct caspase inhibitor, XIAP is a crucial modulator of the equilibrium between cell survival and cell death which is effected by intestinal epithelial cells detachment from ECM.

The X-linked Inhibitor of Apoptosis, XIAP, is a key member of the newly discovered family of intrinsic inhibitors of apoptosis (IAP) proteins. IAPs block cell death both in vitro and in vivo by virtue of inhibition of distinct caspases.