Apr 30, 2013 · The high apoptosis induced by DEPDC1A knockdown in XG2 cells carrying mutated TP53 genes could be understandable in light of data with wild-type TP53 HMCLs. In these cells, there was no induction of p21 Cip1 due to lack of wild-type p53.

It has been proposed that the functions of the cyclin-dependent kinase inhibitors p21 (Cip1/Waf1) and p27Kip1 are limited to cell cycle control at the G1/S-phase transition and in the maintenance of cellular quiescence.

In this review, we will focus on the multiple functions of p21 in cell cycle regulation, apoptosis and gene transcription after DNA damage and briefly discuss the pathways and factors that have critical roles in p21 expression and activity.

Jun 1, 2016 · The inhibitory effect of P21 on cell cycle progression correlates with its nuclear localization. P21 can be induced by both p53-dependent and p53-independent mechanisms. Some other important functions attributed to p21 include transcriptional regulation, modulation or inhibition of apoptosis.

Apr 16, 2018 · In this study, we identified USP11 as the first deubiquitylase that directly reverses p21 polyubiquitylation and stabilizes the p21 protein. We also demonstrated that the USP11-p21 axis is critical for regulating cell-cycle progression and DNA damage-induced G2 arrest.

We found that expression of wild-type p21 (p21WT), not mutant p21 (p21PCNA−) lacking the interaction with proliferating cell nuclear antigen (PCNA), caused G2 cell cycle arrest in p53-deficient DLD1 colon cancer cell line after the DNA damage by treatment with cis-diamminedichloroplatinum (II).

Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin–CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors.

Upon DNA damage or other stressors, the tumor suppressor p53 is activated, leading to transient expression of the cyclin-dependent kinase inhibitor (CKI) p21. This either triggers momentary G1 cell cycle arrest or leads to a chronic state of senescence or …

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Aug 19, 2019 · We found that in the initial stage of damage, where extracellular matrix was not yet deposited, proximal tubular cells arrested at G2 of the cell cycle. Further analyses indicated that the cyclin-dependent kinase inhibitor p21 is partially involved in the G2 arrest after the damage.