GPX4: The core downstream antioxidant of system X c − /GSH/GPX4 axis. As the cornerstone of antioxidant defense, GPX4, a phospholipid peroxidation inhibitor, is the only glutathione …

Feb 20, 2021 · Erastin depletes levels of the antioxidant selenoproteins GPX4 and GPX1 in breast cancer cells by inhibiting xCT-dependent extracellular reduction which is required for …

Aug 29, 2022 · This review aims to present the current understanding of the mechanism of ferroptosis based on the System X c-/GSH/GPX4 axis in the treatment of drug-resistant solid …

Feb 20, 2021 · These findings support the notion that xCT drives the expression of GPX4 , and that the elevated expression of both SLC7A11 and SLC3A2 is a determinant for increased …

Feb 27, 2024 · xCT/GPX4 axis is involved in the tumor resistance against radiation through the inhibition of ferroptosis in OSCC. Furthermore, radiotherapy combined with ferroptosis …

The xCT-GSH-GPX4 axis is the ideal downstream component of ferroptosis that exerts a powerful protective mechanism. Notably, classical xCT inhibitors were capable of leading to the …

Feb 18, 2025 · Glutathione peroxidase 4 (GPX4) utilizes reduced glutathione (GSH) as a cofactor to detoxify lipid peroxidation and suppress ferroptosis in a GPX4-dependent manner. 12,13 …

Recent studies revealed that SLC7A11 overexpression promotes tumor growth partly through suppressing ferroptosis, a form of regulated cell death induced by excessive lipid peroxidation.

Jan 1, 2025 · Gastrodin activates the xCT/GPX4 pathway to promote GSH production and reduce lipid peroxides, while inhibiting the ACSL4/LPCAT3 pathway to prevent ferroptosis. These …

The expression levels of xCT ( p < 0.05) and GPX4 ( p < 0.001) were reduced after treatment with erastin and blister fluids, while this phenomenon was reversed by pretreatment with …